Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding.

Lin, Sheng; Chen, Zimin; Zhang, Xindan; Wen, Ao; Yuan, Xin; Yu, Chongzhang; Yang, Jing; He, Bin; Cao, Yu; Lu, Guangwen

Lin, Sheng; Chen, Zimin; Zhang, Xindan; Wen, Ao; Yuan, Xin; Yu, Chongzhang; Yang, Jing; He, Bin; Cao, Yu; Lu, Guangwen.

Lin S; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Chen Z; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Zhang X; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Wen A; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Yuan X; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Yu C; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Yang J; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
He B; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Cao Y; West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
Lu G; Disaster Medicine Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.

Signal Transduct Target Ther ; 7(1): 56, 2022 02 21.

Article in English | MEDLINE | ID: covidwho-1704266

Subject(s)

Angiotensin-Converting Enzyme 2/metabolism; Antibodies, Neutralizing/pharmacology; Antibodies, Viral/pharmacology; SARS-CoV-2/drug effects; Spike Glycoprotein, Coronavirus/antagonists & inhibitors; Angiotensin-Converting Enzyme 2/genetics; Angiotensin-Converting Enzyme 2/immunology; Antibodies, Neutralizing/biosynthesis; Antibodies, Neutralizing/genetics; Antibodies, Viral/biosynthesis; Antibodies, Viral/genetics; Antibody Affinity; Gene Expression; Humans; Immune Evasion; Models, Molecular; Mutation; Neutralization Tests; Protein Binding/drug effects; Protein Conformation; Protein Interaction Domains and Motifs; Receptors, Virus/genetics; Receptors, Virus/immunology; SARS-CoV-2/growth & development; SARS-CoV-2/immunology; Spike Glycoprotein, Coronavirus/genetics; Spike Glycoprotein, Coronavirus/immunology

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / Antibodies, Viral Topics: Variants Limits: Humans Language: English Journal: Signal Transduct Target Ther Year: 2022 Document Type: Article Affiliation country: S41392-022-00914-2

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google