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SARS-CoV-2 in Spent Dialysate from Chronic Peritoneal Dialysis Patients with COVID-19.
Wang, Xiaoling; Patel, Amrish; Tisdale, Lela; Haq, Zahin; Ye, Xiaoling; Lasky, Rachel; Preciado, Priscila; Tao, Xia; Dias, Gabriela Ferreira; Chao, Joshua E; Hakim, Mohamad; Han, Maggie; Thwin, Ohnmar; Raimann, Jochen; Chatoth, Dinesh; Kotanko, Peter; Grobe, Nadja.
  • Wang X; Renal Research Institute, New York, New York.
  • Patel A; Renal Research Institute, New York, New York.
  • Tisdale L; Renal Research Institute, New York, New York.
  • Haq Z; Renal Research Institute, New York, New York.
  • Ye X; Renal Research Institute, New York, New York.
  • Lasky R; Fresenius Medical Care North America, Waltham, Massachusetts.
  • Preciado P; Renal Research Institute, New York, New York.
  • Tao X; Renal Research Institute, New York, New York.
  • Dias GF; Renal Research Institute, New York, New York.
  • Chao JE; Pontifical Catholic University of Paraná, Curitiba, Brazil.
  • Hakim M; Renal Research Institute, New York, New York.
  • Han M; Renal Research Institute, New York, New York.
  • Thwin O; Renal Research Institute, New York, New York.
  • Raimann J; Renal Research Institute, New York, New York.
  • Chatoth D; Renal Research Institute, New York, New York.
  • Kotanko P; Fresenius Kidney Care, Atlanta, Georgia.
  • Grobe N; Renal Research Institute, New York, New York.
Kidney360 ; 2(1): 86-89, 2021 01 28.
Article in English | MEDLINE | ID: covidwho-1776877
ABSTRACT

Background:

To date, it is unclear whether SARS-CoV-2 is present in spent dialysate from patients with COVID-19 on peritoneal dialysis (PD). Our aim was to assess the presence or absence of SARS-CoV-2 in spent dialysate from patients on chronic PD who had a confirmed diagnosis of COVID-19.

Methods:

Spent PD dialysate samples from patients on PD who were positive for COVID-19 were collected between March and August 2020. The multiplexed, real-time RT-PCR assay contained primer/probe sets specific to different SARS-CoV-2 genomic regions and to bacteriophage MS2 as an internal process control for nucleic acid extraction. Demographic and clinical data were obtained from patients' electronic health records.

Results:

A total of 26 spent PD dialysate samples were collected from 11 patients from ten dialysis centers. Spent PD dialysate samples were collected, on average, 25±13 days (median, 20; range, 10-45) after the onset of symptoms. The temporal distance of PD effluent collection relative to the closest positive nasal-swab RT-PCR result was 15±11 days (median, 14; range, 1-41). All 26 PD effluent samples tested negative at three SARS-CoV-2 genomic regions.

Conclusions:

Our findings indicate the absence of SARS-CoV-2 in spent PD dialysate collected at ≥10 days after the onset of COVID-19 symptoms. We cannot rule out the presence of SARS-CoV-2 in spent PD dialysate in the early stage of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peritoneal Dialysis / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Kidney360 Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peritoneal Dialysis / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Kidney360 Year: 2021 Document Type: Article