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PI3K-α/mTOR/BRD4 inhibitor alone or in combination with other anti-virals blocks replication of SARS-CoV-2 and its variants of concern including Delta and Omicron.
Acharya, Arpan; Pathania, Anup S; Pandey, Kabita; Thurman, Michellie; Vann, Kendra R; Kutateladze, Tatiana G; Challagundala, Kishore B; Durden, Donald L; Byrareddy, Siddappa N.
  • Acharya A; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Pathania AS; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, Nebraska, USA.
  • Pandey K; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Thurman M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Vann KR; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Challagundala KB; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, Nebraska, USA.
  • Durden DL; The Child Health Research Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Byrareddy SN; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Moores Cancer Center, UC San Diego School of Medicine, La Jolla, California, USA.
Clin Transl Med ; 12(4): e806, 2022 04.
Article in English | MEDLINE | ID: covidwho-1777546
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phosphoinositide-3 Kinase Inhibitors / SARS-CoV-2 / COVID-19 Drug Treatment Topics: Variants Limits: Humans Language: English Journal: Clin Transl Med Year: 2022 Document Type: Article Affiliation country: Ctm2.806

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phosphoinositide-3 Kinase Inhibitors / SARS-CoV-2 / COVID-19 Drug Treatment Topics: Variants Limits: Humans Language: English Journal: Clin Transl Med Year: 2022 Document Type: Article Affiliation country: Ctm2.806