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Glycosylation of viral proteins: Implication in virus-host interaction and virulence.
Feng, Tingting; Zhang, Jinyu; Chen, Zhiqian; Pan, Wen; Chen, Zhengrong; Yan, Yongdong; Dai, Jianfeng.
  • Feng T; Jiangsu Key Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, Suzhou, China.
  • Zhang J; Jiangsu Key Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, Suzhou, China.
  • Chen Z; Jiangsu Key Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, Suzhou, China.
  • Pan W; Jiangsu Key Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, Suzhou, China.
  • Chen Z; Department of Respiratory Medicine, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
  • Yan Y; Department of Respiratory Medicine, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
  • Dai J; Jiangsu Key Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, Suzhou, China.
Virulence ; 13(1): 670-683, 2022 12.
Article in English | MEDLINE | ID: covidwho-1791073
ABSTRACT
Glycans are among the most important cell molecular components. However, given their structural diversity, their functions have not been fully explored. Glycosylation is a vital post-translational modification for various proteins. Many bacteria and viruses rely on N-linked and O-linked glycosylation to perform critical biological functions. The diverse functions of glycosylation on viral proteins during viral infections, including Dengue, Zika, influenza, and human immunodeficiency viruses as well as coronaviruses have been reported. N-linked glycosylation is the most common form of protein modification, and it modulates folding, transportation and receptor binding. Compared to N-linked glycosylation, the functions of O-linked viral protein glycosylation have not been comprehensively evaluated. In this review, we summarize findings on viral protein glycosylation, with particular attention to studies on N-linked glycosylation in viral life cycles. This review informs the development of virus-specific vaccines or inhibitors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zika Virus / Zika Virus Infection Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Virulence Year: 2022 Document Type: Article Affiliation country: 21505594.2022.2060464

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zika Virus / Zika Virus Infection Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Virulence Year: 2022 Document Type: Article Affiliation country: 21505594.2022.2060464