Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic.
Nat Rev Genet
; 23(9): 547-562, 2022 09.
Article
in English
| MEDLINE | ID: covidwho-1805619
ABSTRACT
Determining the transmissibility, prevalence and patterns of movement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to our understanding of the impact of the pandemic and to the design of effective control strategies. Phylogenies (evolutionary trees) have provided key insights into the international spread of SARS-CoV-2 and enabled investigation of individual outbreaks and transmission chains in specific settings. Phylodynamic approaches combine evolutionary, demographic and epidemiological concepts and have helped track virus genetic changes, identify emerging variants and inform public health strategy. Here, we review and synthesize studies that illustrate how phylogenetic and phylodynamic techniques were applied during the first year of the pandemic, and summarize their contributions to our understanding of SARS-CoV-2 transmission and control.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pandemics
/
COVID-19
Type of study:
Observational study
/
Randomized controlled trials
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
Nat Rev Genet
Journal subject:
Genetics
Year:
2022
Document Type:
Article
Affiliation country:
S41576-022-00483-8
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