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Recurrent SARS-CoV-2 Infection and Impaired Immunologic Response in a Pediatric Oncologic Patient While Treated With Radiochemotherapy.
Eichholz, Thomas; Arendt, Anne-Marie; Holzer, Ursula; Seitz, Christian; Rabsteyn, Armin; Ganzenmueller, Tina; Klein, Reinhild; Walz, Juliane; Lang, Peter.
  • Eichholz T; From the University Children's Hospital, Eberhard Karls University, Tuebingen, Germany.
  • Arendt AM; From the University Children's Hospital, Eberhard Karls University, Tuebingen, Germany.
  • Holzer U; From the University Children's Hospital, Eberhard Karls University, Tuebingen, Germany.
  • Seitz C; From the University Children's Hospital, Eberhard Karls University, Tuebingen, Germany.
  • Rabsteyn A; From the University Children's Hospital, Eberhard Karls University, Tuebingen, Germany.
  • Ganzenmueller T; Institute for Medical Virology and Epidemiology of Viral Diseases, Eberhard Karls University, Tuebingen, Germany.
  • Klein R; Department of Internal Medicine II, Hematology/Oncology, Eberhard Karls University, Tuebingen, Germany.
  • Walz J; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, Tuebingen, Germany.
  • Lang P; From the University Children's Hospital, Eberhard Karls University, Tuebingen, Germany.
Pediatr Infect Dis J ; 41(6): e259-e262, 2022 06 01.
Article in English | MEDLINE | ID: covidwho-1806684
ABSTRACT
Immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients with malignant disease may be affected by tumor therapy. Here, we report the case of a child with rhabdomyosarcoma and recurrent SARS-CoV-2 infection. Immunologic responses, analyzed by T-cell activity and anti-viral IgG levels, were impaired and not durable as a result of intensive radiochemotherapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Case report Limits: Child / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article Affiliation country: Inf.0000000000003515

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Case report Limits: Child / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2022 Document Type: Article Affiliation country: Inf.0000000000003515