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Structural insights into ORF10 recognition by ZYG11B.
Zhang, Bing; Li, Yao; Feng, Qiqi; Song, Lili; Dong, Cheng; Yan, Xiaojie.
  • Zhang B; Department of Biochemistry and Molecular Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 3000
  • Li Y; Department of Biochemistry and Molecular Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 3000
  • Feng Q; Department of Biochemistry and Molecular Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 3000
  • Song L; Department of Immunology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tian
  • Dong C; Department of Biochemistry and Molecular Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 3000
  • Yan X; Department of Biochemistry and Molecular Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 3000
Biochem Biophys Res Commun ; 616: 14-18, 2022 08 06.
Article in English | MEDLINE | ID: covidwho-1850694
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a major threat to human health. As a unique putative protein of SARS-CoV-2, the N-terminus of ORF10 can be recognized by ZYG11B, a substrate receptor of the Cullin 2-RING E3 ubiquitin ligase (CRL2). Here we elucidated recognition mechanism of ORF10 N-terminus by ZYG11B through presenting the crystal structure of ZYG11B bound to ORF10 N-terminal peptide. Our work expands the current understanding of ORF10 interaction with ZYG11B, and may also inspire the development of novel therapies for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Open Reading Frames / Cell Cycle Proteins / Ubiquitin-Protein Ligases / COVID-19 Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Open Reading Frames / Cell Cycle Proteins / Ubiquitin-Protein Ligases / COVID-19 Limits: Humans Language: English Journal: Biochem Biophys Res Commun Year: 2022 Document Type: Article