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Principles of SARS-CoV-2 glycosylation.
Chawla, Himanshi; Fadda, Elisa; Crispin, Max.
  • Chawla H; School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.
  • Fadda E; Department of Chemistry and Hamilton Institute, Maynooth University, Maynooth, Kildare, Ireland.
  • Crispin M; School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK. Electronic address: max.crispin@soton.ac.uk.
Curr Opin Struct Biol ; 75: 102402, 2022 08.
Article in English | MEDLINE | ID: covidwho-1852027
ABSTRACT
The structure and post-translational processing of the SARS-CoV-2 spike glycoprotein (S) is intimately associated with the function of the virus and of sterilising vaccines. The surface of the S protein is extensively modified by glycans, and their biosynthesis is driven by both the wider cellular context, and importantly, the underlining protein structure and local glycan density. Comparison of virally derived S protein with both recombinantly derived and adenovirally induced proteins, reveal hotspots of protein-directed glycosylation that drive conserved glycosylation motifs. Molecular dynamics simulations revealed that, while the S surface is extensively shielded by N-glycans, it presents regions vulnerable to neutralising antibodies. Furthermore, glycans have been shown to influence the accessibility of the receptor binding domain and the binding to the cellular receptor. The emerging picture is one of unifying, principles of S protein glycosylation and an intimate role of glycosylation in immunogen structure and efficacy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Curr Opin Struct Biol Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: J.sbi.2022.102402

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Curr Opin Struct Biol Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: J.sbi.2022.102402