Characteristics of SARS-CoV-2 infection in patients with prostate neoplasm: case report

ABSTRACT

Oncological patients are a vulnerable group to SARS-CoV-2 infection, which is caused by a decrease in the functionality of the immune system through its fight against cancer cells, but also through treatment. This article aims to a better understanding of the pathogenetic mechanism by which these events occur, in particular the connection between TMPRSS2 protein, antiandrogenic therapy, and repeated SARS-CoV-2 infections. The deepening of the possible mechanisms underlying the interaction between COVID-19 and prostate cancer alludes to a potential association between SARS-CoV-2 receptors on host epithelial cells, but also to how anti-androgenic therapy influences the course of the disease.