The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?
Acta Clin Belg
; 77(1): 211-218, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-1900965
ABSTRACT
Angiotensin-converting enzyme 2 (ACE 2) is the entry receptor for the novel coronavirus SARS-CoV-2, the aetiological agent of COVID-19. At the same time, ACE 2 expression decreases during COVID-19. Two seemingly contradictory relationships between the expression of ACE 2 and COVID-19 have been reported. Increased level of expression of ACE 2 may be a risk factor for the development of COVID-19 infection, while reduced ACE 2 expression during COVID-19 leads to acute respiratory distress syndrome. This article provides a comprehensive overview of available scientific knowledge about the role of ACE 2 in the pathogenesis of COVID-19, which is available up to current day. Also, it discusses unknown factors that we will have to reveal in order to understand the whole role of ACE 2 in the pathogenesis of COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Angiotensin-Converting Enzyme 2
/
COVID-19
Type of study:
Etiology study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Acta Clin Belg
Year:
2022
Document Type:
Article
Affiliation country:
17843286.2020.1786324
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