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The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?
Klhufek, Josef.
  • Klhufek J; Department of Pharmacy, T. Bata Regional Hospital, Zlín, Czech Republic.
Acta Clin Belg ; 77(1): 211-218, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1900965
ABSTRACT
Angiotensin-converting enzyme 2 (ACE 2) is the entry receptor for the novel coronavirus SARS-CoV-2, the aetiological agent of COVID-19. At the same time, ACE 2 expression decreases during COVID-19. Two seemingly contradictory relationships between the expression of ACE 2 and COVID-19 have been reported. Increased level of expression of ACE 2 may be a risk factor for the development of COVID-19 infection, while reduced ACE 2 expression during COVID-19 leads to acute respiratory distress syndrome. This article provides a comprehensive overview of available scientific knowledge about the role of ACE 2 in the pathogenesis of COVID-19, which is available up to current day. Also, it discusses unknown factors that we will have to reveal in order to understand the whole role of ACE 2 in the pathogenesis of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Etiology study / Prognostic study Limits: Humans Language: English Journal: Acta Clin Belg Year: 2022 Document Type: Article Affiliation country: 17843286.2020.1786324

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Type of study: Etiology study / Prognostic study Limits: Humans Language: English Journal: Acta Clin Belg Year: 2022 Document Type: Article Affiliation country: 17843286.2020.1786324