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Altered brain regional homogeneity is associated with depressive symptoms in COVID-19.
Cattarinussi, Giulia; Miola, Alessandro; Trevisan, Nicolò; Valeggia, Silvia; Tramarin, Elena; Mucignat, Carla; Morra, Francesco; Minerva, Matteo; Librizzi, Giovanni; Bordin, Anna; Causin, Francesco; Ottaviano, Giancarlo; Antonini, Angelo; Sambataro, Fabio; Manara, Renzo.
  • Cattarinussi G; Department of Neuroscience (DNS), University of Padova, Padua, Italy; Padua Neuroscience Center, University of Padova, Padua, Italy.
  • Miola A; Department of Neuroscience (DNS), University of Padova, Padua, Italy; Padua Neuroscience Center, University of Padova, Padua, Italy.
  • Trevisan N; Department of Neuroscience (DNS), University of Padova, Padua, Italy; Padua Neuroscience Center, University of Padova, Padua, Italy.
  • Valeggia S; Department of Medicine-DIMED, Radiology Institute, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.
  • Tramarin E; Department of Medicine-DIMED, Radiology Institute, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.
  • Mucignat C; Department of Molecular Medicine, University of Padova, Padua, Italy.
  • Morra F; Department of Medicine-DIMED, Radiology Institute, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.
  • Minerva M; Department of Medicine-DIMED, Radiology Institute, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.
  • Librizzi G; Department of Medicine-DIMED, Radiology Institute, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.
  • Bordin A; Department of Neurosciences, Otolaryngology Section University of Padova, Padua, Italy.
  • Causin F; Neuroradiology Unit, Neurosciences Department, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.
  • Ottaviano G; Department of Neurosciences, Otolaryngology Section University of Padova, Padua, Italy.
  • Antonini A; Padua Neuroscience Center, University of Padova, Padua, Italy; Parkinson and Movement Disorders Unit, Study Center for Neurodegeneration (CESNE), Department of Neurosciences, University of Padova, Padua, Italy.
  • Sambataro F; Department of Neuroscience (DNS), University of Padova, Padua, Italy; Padua Neuroscience Center, University of Padova, Padua, Italy. Electronic address: fabio.sambataro@unipd.it.
  • Manara R; Neuroradiology Unit, Neurosciences Department, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.
J Affect Disord ; 313: 36-42, 2022 09 15.
Article in English | MEDLINE | ID: covidwho-1907233
ABSTRACT

BACKGROUND:

COVID-19 is an infectious disease that has spread worldwide in 2020, causing a severe pandemic. In addition to respiratory symptoms, neuropsychiatric manifestations are commonly observed, including chronic fatigue, depression, and anxiety. The neural correlates of neuropsychiatric symptoms in COVID-19 are still largely unknown.

METHODS:

A total of 79 patients with COVID-19 (COV) and 17 healthy controls (HC) underwent 3 T functional magnetic resonance imaging at rest, as well as structural imaging. Regional homogeneity (ReHo) was calculated. We also measured depressive symptoms with the Patient Health Questionnaire (PHQ-9), anxiety using the General Anxiety Disorder 7-item scale, and fatigue with the Multidimension Fatigue Inventory.

RESULTS:

In comparison with HC, COV showed significantly higher depressive scores. Moreover, COV presented reduced ReHo in the left angular gyrus, the right superior/middle temporal gyrus and the left inferior temporal gyrus, and higher ReHo in the right hippocampus. No differences in gray matter were detected in these areas. Furthermore, we observed a negative correlation between ReHo in the left angular gyrus and PHQ-9 scores and a trend toward a positive correlation between ReHo in the right hippocampus and PHQ-9 scores.

LIMITATIONS:

Heterogeneity in the clinical presentation in COV, the different timing from the first positive molecular swab test to the MRI, and the cross-sectional design of the study limit the generalizability of our findings.

CONCLUSIONS:

Our results suggest that COVID-19 infection may contribute to depressive symptoms via a modulation of local functional connectivity in cortico-limbic circuits.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Depression / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Affect Disord Year: 2022 Document Type: Article Affiliation country: J.jad.2022.06.061

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Depression / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Affect Disord Year: 2022 Document Type: Article Affiliation country: J.jad.2022.06.061