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SARS-CoV-2 Viral Load Analysis at Low and High Altitude: A Case Study from Ecuador.
Ortiz-Prado, Esteban; Simbaña-Rivera, Katherine; Fernandez-Naranjo, Raul; Vásconez, Jorge Eduardo; Henriquez-Trujillo, Aquiles R; Vallejo-Janeta, Alexander Paolo; Rivera-Olivero, Ismar A; Lozada, Tannya; Viscor, Gines; Garcia-Bereguiain, Miguel Angel.
  • Ortiz-Prado E; One Health Research Group, Faculty of Medicine, Universidad de las Américas, Quito 170124, Ecuador.
  • Simbaña-Rivera K; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.
  • Fernandez-Naranjo R; One Health Research Group, Faculty of Medicine, Universidad de las Américas, Quito 170124, Ecuador.
  • Vásconez JE; One Health Research Group, Faculty of Medicine, Universidad de las Américas, Quito 170124, Ecuador.
  • Henriquez-Trujillo AR; One Health Research Group, Faculty of Medicine, Universidad de las Américas, Quito 170124, Ecuador.
  • Vallejo-Janeta AP; One Health Research Group, Faculty of Medicine, Universidad de las Américas, Quito 170124, Ecuador.
  • Rivera-Olivero IA; Laboratorio de Investigación, Universidad de las Américas, Quito 170124, Ecuador.
  • Lozada T; One Health Research Group, Faculty of Medicine, Universidad de las Américas, Quito 170124, Ecuador.
  • Viscor G; Laboratorio de Investigación, Universidad de las Américas, Quito 170124, Ecuador.
  • Garcia-Bereguiain MA; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.
Int J Environ Res Public Health ; 19(13)2022 06 28.
Article in English | MEDLINE | ID: covidwho-1911387
ABSTRACT
SARS-CoV-2 has spread throughout the world, including remote areas such as those located at high altitudes. There is a debate about the role of hypobaric hypoxia on viral transmission and COVID-19 incidence. A descriptive cross-sectional analysis of SARS-CoV-2 infection and viral load among patients living at low (230 m) and high altitude (3800 m) in Ecuador was completed. Within these two communities, the total number of infected people at the time of the study was 108 cases (40.3%). The COVID-19 incidence proportion at low altitude was 64% while at high altitude was 30.3%. The mean viral load from those patients who tested positive was 3,499,184 copies/mL (SD = 23,931,479 copies/mL). At low altitude (Limoncocha), the average viral load was 140,223.8 copies/mL (SD = 990,840.9 copies/mL), while for the high altitude group (Oyacachi), the mean viral load was 6,394,789 copies/mL (SD = 32,493,469 copies/mL). We found no statistically significant differences when both results were compared (p = 0.056). We found no significant differences across people living at low or high altitude; however, men and younger populations had higher viral load than women older populations, respectively.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: South America / Ecuador Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19137945

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: South America / Ecuador Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19137945