Heart rate variability and adrenal size provide clues to sudden cardiac death in hospitalized COVID-19 patients.
J Crit Care
; 71: 154114, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-1936752
ABSTRACT
PURPOSE:
To examine the association between a measure of heart rate variability and sudden cardiac death (SCD) in COVID-19 patients.METHODS:
Patients with SARS-COV-2 infection admitted to Columbia University Irving Medical Center who died between 4/25/2020 and 7/14/2020 and had an autopsy were examined for root mean square of successive differences (RMSSD), organ weights, and evidence of SCD.RESULTS:
Thirty COVID-19 patients were included and 12 had SCD. The RMSSD over 7 days without vs with SCD was median 0.0129 (IQR 0.0074-0.026) versus 0.0098 (IQR 0.0056-0.0197), p < 0.0001. The total adjusted adrenal weight of the non-SCD group was 0.40 g/kg (IQR 0.35-0.55) versus 0.25 g/kg (IQR 0.21-0.31) in the SCD group, p = 0.0007.CONCLUSIONS:
Hospitalized patients with COVID-19 who experienced SCD had lower parasympathetic activity (RMSSD) and smaller sized adrenal glands. Further research is required to replicate these findings.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Crit Care
Journal subject:
Critical Care
Year:
2022
Document Type:
Article
Affiliation country:
J.jcrc.2022.154114
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