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Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron.
Liu, Hejun; Kaku, Chengzi I; Song, Ge; Yuan, Meng; Andrabi, Raiees; Burton, Dennis R; Walker, Laura M; Wilson, Ian A.
  • Liu H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Kaku CI; Adimab, LLC, Lebanon, NH, USA.
  • Song G; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Andrabi R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Walker LM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Wilson IA; Adimab, LLC, Lebanon, NH, USA. laura.walker@adimab.com.
Commun Biol ; 5(1): 766, 2022 07 29.
Article in English | MEDLINE | ID: covidwho-1967631
ABSTRACT
Studying the antibody response to SARS-CoV-2 informs on how the human immune system can respond to antigenic variants as well as other SARS-related viruses. Here, we structurally identified a YYDRxG motif encoded by IGHD3-22 in CDR H3 that facilitates antibody targeting to a functionally conserved epitope on the SARS-CoV-2 receptor binding domain. A computational search for a YYDRxG pattern in publicly available sequences uncovered 100 such antibodies, many of which can neutralize SARS-CoV-2 variants and SARS-CoV. Thus, the YYDRxG motif represents a common convergent solution for the human humoral immune system to target sarbecoviruses including the Omicron variant. These findings suggest an epitope-targeting strategy to identify potent and broadly neutralizing antibodies for design of pan-sarbecovirus vaccines and antibody therapeutics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Commun Biol Year: 2022 Document Type: Article Affiliation country: S42003-022-03700-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Commun Biol Year: 2022 Document Type: Article Affiliation country: S42003-022-03700-6