Cerebral microvascular injuries in severe COVID-19 infection: progression of white matter hyperintensities post-infection.
BMJ Case Rep
; 15(9)2022 Sep 13.
Article
in English
| MEDLINE | ID: covidwho-2029494
ABSTRACT
A range of neuroradiological findings has been reported in patients with COVID-19, some mimicking cerebral small vessel disease (CSVD). We present a case of a man in his 50s with severe COVID-19, who was Glasgow Coma Scale 3 and tetraparetic after sedation was ceased in the intensive care unit. Return of consciousness and motor activity was slow. An MRI 1 month after debut of symptoms demonstrated white matter hyperintensities on T2-weighted Fluid Attenuated Inversion Recovery (T2-FLAIR) and many small areas with impaired diffusion in primarily supratentorial and infratentorial white matter on Diffusion-Weighted Imaging (DWI). In the following months, the patient made a remarkable clinical recovery. Despite clinical improvement, an MRI after 7 months showed that white matter hyperintensities had progressed and become confluent. Both MRIs demonstrated findings resembling CSVD, which could relate to a COVID-19-specific process affecting cerebral microvasculature.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
White Matter
/
Brain Injuries, Traumatic
/
COVID-19
Type of study:
Case report
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Bcr-2022-249156
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