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Clinical features and effectiveness of Chinese medicine in patients with COVID-19 from overseas: A retrospective study in Xiamen, China.
Huang, Yu-Xuan; Li, Na-Fen; Li, Chen-Yao; Zheng, Fang-Ping; Yao, Xiang-Yang; Lin, Bao-Hua; Huang, Xian-Zhong; Zhao, Neng-Jiang; Yang, Jia-Yong; Chen, Qiu-Min; Zhang, Man-Man; Yi, Li-Tao; Chen, Xue-Qin.
  • Huang YX; The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Li NF; Fujian University of Traditional Chinese Medicine, Fuzhou, China.
  • Li CY; The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Zheng FP; Fujian University of Traditional Chinese Medicine, Fuzhou, China.
  • Yao XY; The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Lin BH; Fujian University of Traditional Chinese Medicine, Fuzhou, China.
  • Huang XZ; Department of Traditional Chinese Medicine, Xiamen Maluan Wan Hospital, Xiamen, China.
  • Zhao NJ; Xinglin Branch of the First Hospital of Xiamen University, Designated Hospital for Treatment of Novel Coronavirus Pneumonia in Xiamen, Xiamen, China.
  • Yang JY; Xinglin Branch of the First Hospital of Xiamen University, Designated Hospital for Treatment of Novel Coronavirus Pneumonia in Xiamen, Xiamen, China.
  • Chen QM; The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Zhang MM; The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Yi LT; The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Chen XQ; Xinglin Branch of the First Hospital of Xiamen University, Designated Hospital for Treatment of Novel Coronavirus Pneumonia in Xiamen, Xiamen, China.
Front Public Health ; 10: 1038017, 2022.
Article in English | MEDLINE | ID: covidwho-2109888
ABSTRACT
COVID-19, referred to as new coronary pneumonia, is an acute infectious disease caused by a new type of coronavirus SARS-CoV-2. To evaluate the effect of integrated Chinese medicine and Western medicine in patients with COVID-19 from overseas. Data were collected from 178 COVID-19 patients overseas at First Affiliated Hospital of Xiamen University from April 1, 2021 to July 31, 2021. These patients received therapy of integrated Chinese medicine and western medicine. Demographic data and clinical characteristics were extracted and analyzed. In addition, the prescription which induced less length of PCR positive days and hospitalization days than the median value was obtained. The top 4 frequently used Chinese medicine and virus-related genes were analyzed by network pharmacology and bioinformatics analysis. According to the chest computed tomography (CT) measurement, abnormal lung findings were observed in 145 subjects. The median length of positive PCR/hospitalization days was 7/7 days for asymptomatic subjects, 14/24 days for mild subjects, 10/15 days for moderate subjects, and 14/20 days for severe subjects. The most frequently used Chinese medicine were Scutellaria baicalensis (Huangqin), Glycyrrhiza uralensis (Gancao), Bupleurum chinense (Chaihu), and Pinellia ternata (Banxia). The putative active ingredients were baicalin, stigmasterol, sigmoidin-B, cubebin, and troxerutin. ACE, SARS-CoV-2 3CL, SARS-CoV-2 Spike, SARS-CoV-2 ORF7a, and caspase-6 showed good binding properties to active ingredients. In conclusion, the clinical results showed that integrated Chinese medicine and Western medicine are effective in treating COVID-19 patients from overseas. Based on the clinical outcomes, the putative ingredients from Chinese medicine and the potential targets of SARS-CoV-2 were provided, which could provide a reference for the clinical application of Chinese medicine in treating COVID-19 worldwide.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Front Public Health Year: 2022 Document Type: Article Affiliation country: Fpubh.2022.1038017

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Front Public Health Year: 2022 Document Type: Article Affiliation country: Fpubh.2022.1038017