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Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus-Host Interactions.
Zhang, Yuanzhu; Chen, Yiwu; Zhou, Jian; Wang, Xi; Ma, Lerong; Li, Jianing; Yang, Lin; Yuan, Hongming; Pang, Daxin; Ouyang, Hongsheng.
  • Zhang Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Chen Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Zhou J; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Wang X; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Ma L; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Li J; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Yang L; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Yuan H; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
  • Pang D; Chongqing Research Institute, Jilin University, Chongqing 401120, China.
  • Ouyang H; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China.
Viruses ; 14(11)2022 Nov 02.
Article in English | MEDLINE | ID: covidwho-2123861
ABSTRACT
The porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family, causing deadly watery diarrhea in newborn piglets. The global pandemic of PEDV, with significant morbidity and mortality, poses a huge threat to the swine industry. The currently developed vaccines and drugs are only effective against the classic GI strains that were prevalent before 2010, while there is no effective control against the GII variant strains that are currently a global pandemic. In this review, we summarize the latest progress in the biology of PEDV, including its transmission and origin, structure and function, evolution, and virus-host interaction, in an attempt to find the potential virulence factors influencing PEDV pathogenesis. We conclude with the mechanism by which PEDV components antagonize the immune responses of the virus, and the role of host factors in virus infection. Essentially, this review serves as a valuable reference for the development of attenuated virus vaccines and the potential of host factors as antiviral targets for the prevention and control of PEDV infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Coronavirus Infections / Coronavirus / Porcine epidemic diarrhea virus Type of study: Observational study Topics: Vaccines / Variants Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: V14112434

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / Coronavirus Infections / Coronavirus / Porcine epidemic diarrhea virus Type of study: Observational study Topics: Vaccines / Variants Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: V14112434