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Evolutionary plasticity of zoonotic porcine Deltacoronavirus (PDCoV): genetic characteristics and geographic distribution.
Bahoussi, Amina Nawal; Wang, Pei-Hua; Shah, Pir Tariq; Bu, Hongli; Wu, Changxin; Xing, Li.
  • Bahoussi AN; Institutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan, 030006, Shanxi province, China.
  • Wang PH; Institutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan, 030006, Shanxi province, China.
  • Shah PT; Institutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan, 030006, Shanxi province, China.
  • Bu H; Department of Laboratory Medicine, The Fourth People's Hospital of Taiyuan, 231 Xikuang St, Taiyuan, 030053, Shanxi province, China.
  • Wu C; Institutes of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan, 030006, Shanxi province, China. cxw20@sxu.edu.cn.
  • Xing L; Shanxi Provincial Key Laboratory of Medical Molecular Cell Biology, Shanxi University, 92 Wucheng Road, Taiyuan, 030006, China. cxw20@sxu.edu.cn.
BMC Vet Res ; 18(1): 444, 2022 Dec 22.
Article in English | MEDLINE | ID: covidwho-2196274
ABSTRACT
The emergence and rapid spread of the acute respiratory syndrome coronavirus-2 have confirmed that animal coronaviruses represent a potential zoonotic source. Porcine deltacoronavirus is a worldwide evolving enteropathogen of swine, detected first in Hong Kong, China, before its global identification. Following the recent detection of PDCoV in humans, we attempted in this report to re-examine the status of PDCoV phylogenetic classification and evolutionary characteristics. A dataset of 166 complete PDCoV genomes was analyzed using the Maximum Likelihood method in IQ-TREE with the best-fitting model GTR + F + I + G4, revealing two major genogroups (GI and GII), with further seven and two sub-genogroups, (GI a-g) and (GII a-b), respectively. PDCoV strains collected in China exhibited the broadest genetic diversity, distributed in all subgenotypes. Thirty-one potential natural recombination events were identified, 19 of which occurred between China strains, and seven involved at least one China strain as a parental sequence. Importantly, we identified a human Haiti PDCoV strain as recombinant, alarming a possible future spillover that could become a critical threat to human health. The similarity and recombination analysis showed that PDCoV spike ORF is highly variable compared to ORFs encoding other structural proteins. Prediction of linear B cell epitopes of the spike glycoprotein and the 3D structural mapping of amino acid variations of two representative strains of GI and GII showed that the receptor-binding domain (RBD) of spike glycoprotein underwent a significant antigenic drift, suggesting its contribution in the genetic diversity and the wider spread of PDCoV.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: BMC Vet Res Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: S12917-022-03554-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Swine Diseases / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: BMC Vet Res Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: S12917-022-03554-4