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Immunogenicity of SARS-CoV-2 vaccines in patients with cancer.
Kakkassery, Helen; Carpenter, Esme; Patten, Piers E M; Irshad, Sheeba.
  • Kakkassery H; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK.
  • Carpenter E; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK.
  • Patten PEM; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK; Department of Haematological Medicine, King's College Hospital, London, UK.
  • Irshad S; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK; Breast Cancer Now Research Unit, King's College London, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address: sheeba.irshad@kcl.ac.uk.
Trends Mol Med ; 28(12): 1082-1099, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2241949
ABSTRACT
Transmission of the SARS-CoV-2 virus and its corresponding disease (COVID-19) has been shown to impose a higher burden on cancer patients than on the general population. Approved vaccines for use include new technology mRNA vaccines such as BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), and nonreplicating viral vector vaccines such as Ad26.COV2.S (Johnson & Johnson) and AZD1222 (AstraZeneca). Impaired or delayed humoral and diminished T-cell responses are evident in patients with cancer, especially in patients with haematological cancers or those under active chemotherapy. Herein we review the current data on vaccine immunogenicity in cancer patients, including recommendations for current practice and future research.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 / Neoplasms Topics: Vaccines Limits: Humans Language: English Journal: Trends Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: J.molmed.2022.07.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 / Neoplasms Topics: Vaccines Limits: Humans Language: English Journal: Trends Mol Med Journal subject: Molecular Biology Year: 2022 Document Type: Article Affiliation country: J.molmed.2022.07.006