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Post Covid-19 Syndrome in Patients with Autoimmune Rheumatic Diseases: Results from the Covid-19 Vaccination in Autoimmune Diseases (Covad) Study
Rheumatology (United Kingdom) ; 62(Supplement 2):ii53, 2023.
Article in English | EMBASE | ID: covidwho-2323430
ABSTRACT
Background/Aims Post COVID-19 syndrome (PCS) is an emerging cause of morbidity and poor quality of life in COVID-19 survivors. We aimed to assess the prevalence, risk factors, outcomes, and association with disease flares of PCS in patients with autoimmune rheumatic diseases (AIRDs) and non-rheumatic autoimmune diseases (nrAIDs), both vulnerable groups understudied in the current literature using data from the 2nd COVID-19 Vaccination in Autoimmune Diseases (COVAD) global multicentre patient self-reported e-survey. Methods The survey was circulated from February to July 2022 by the international COVAD Study Group (157 collaborators from 106 countries), and demographics, comorbidities, AIRD/nrAID status, COVID-19 history, vaccination details, and PROMIS physical and mental function were recorded. PCS was defined as symptom resolution time >90 days following acute COVID-19. Predictors of PCS were analysed using regression models for the different groups. Results 7666 total respondents completed the survey. Of these, 2650 respondents with complete responses had positive COVID-19 infection, and 1677 (45.0% AIRDs, 12.5% nrAIDs, 42.5% HCs) completed the survey >90 days post acute COVID-19. Of these, 136 (8.1%) had PCS. Prevalence of PCS was higher in AIRDs (10.8%) than healthy controls HCs (5.3%) (OR 2.1;95%CI 1.4-3.1, p=0.002). Across the entire cohort, a higher risk of PCS was seen in women (OR 2.9;95%CI 1.1-7.7, p=0.037), patients with long duration of AIRDs/ nrAIDs (OR 1.01;95%CI 1.0-1.02, p=0.016), those with comorbidities (OR 2.8;95%CI 1.4-5.7, p=0.005), and patients requiring oxygen supplementation for severe acute COVID-19 (OR 3.8;95%CI 1.1- 13.6, p=0.039). Among patients with AIRDs, comorbidities (OR 2.0;95%CI 1.08-3.6, p=0.026), and advanced treatment (OR 1.9;95%CI 1.08-3.3, p=0.024), or intensive care (OR 3.8;95%CI 1.01-14.4, p=0.047) for severe COVID-19 were risk factors for PCS. Notably, patients who developed PCS had poorer PROMIS global physical [15 (12-17) vs 12 (9-15)] and mental health [14 (11-16) vs 11 (8-14)] scores than those without PCS. Conclusion Individuals with AIRDs have a greater risk of PCS than HCs. Associated comorbid conditions, and advanced treatment or intensive care unit admission for severe COVID-19 confer a higher risk of PCS. It is imperative to identify risk factors for PCS for immediate multidisciplinary management in anticipation of poor physical and mental health.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Language: English Journal: Rheumatology (United Kingdom) Year: 2023 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Language: English Journal: Rheumatology (United Kingdom) Year: 2023 Document Type: Article