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Implication of COVID-19 pandemic on the incidence of Clostridioides difficile infection in a Greek tertiary hospital.
Karampatakis, Theodoros; Tsergouli, Katerina; Kandilioti, Eleni; Nikopoulou, Anna; Katsifa, Helen; Kachrimanidou, Melina.
  • Karampatakis T; Microbiology Department, Papanikolaou General Hospital, Thessaloniki, Greece.
  • Tsergouli K; Microbiology Department, Agios Pavlos General Hospital, Thessaloniki, Greece.
  • Kandilioti E; Microbiology Department, Papanikolaou General Hospital, Thessaloniki, Greece.
  • Nikopoulou A; Infectious Disease Unit, Papanikolaou General Hospital, Thessaloniki, Greece.
  • Katsifa H; Microbiology Department, Papanikolaou General Hospital, Thessaloniki, Greece.
  • Kachrimanidou M; Department of Microbiology, Medical Faculty, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Med Microbiol ; 72(5)2023 May.
Article in English | MEDLINE | ID: covidwho-2324001
ABSTRACT
Introduction. C. difficile infection (CDI) represents an important global threat. In the COVID-19 era, the multifactorial nature of CDI has emerged.Hypothesis - Aim. The aim was to assess the impact of COVID-19 pandemic on the incidence of CDI in a Greek hospital.Methodology. A retrospective study was performed throughout a 51 month period (January 2018 to March 2022), divided into two periods pre-pandemic (January 2018 to February 2020) and COVID-19 pandemic (March 2020 to March 2022). The effects of the pandemic compared to the pre-pandemic period on the incidence of CDI [expressed as infections per 10 000 bed days (IBD)] were studied using interrupted time-series analysis.Results. Throughout the study, there was an increase in the monthly CDI incidence from 0.00 to 11.77 IBD (P<0.001). Interrupted time-series disclosed an increase in CDI incidence during the pre-pandemic period from 0.00 to 3.36 IBD (P<0.001). During the COVID-19 pandemic period the linear trend for monthly CDI rose from 2.65 to 13.93 IBD (P<0.001). The increase rate was higher during the COVID-19 pandemic period (r2 = +0.47) compared to the pre-pandemic period (r1 = +0.16).Conclusion. A significant increase of CDI incidence was observed, with the rate of the rise being more intense during the COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / Clostridioides difficile / Clostridium Infections / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Year: 2023 Document Type: Article Affiliation country: Jmm.0.001689

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / Clostridioides difficile / Clostridium Infections / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Year: 2023 Document Type: Article Affiliation country: Jmm.0.001689