Efficiency of application of sorbed probiotics in the complex therapy of pneumonia caused by SARS-CoV-2. Quality of life in the short term COVID-19
Infectious Diseases: News, Opinions, Training
; 11(3):69-80, 2022.
Article
in Russian
| EMBASE | ID: covidwho-2324919
ABSTRACT
Aim. To determine the clinical efficacy and safety of the immobilized (sorbed) probiotics Bifidobacterium bifidum 1 (5x108 CFU) and B. bifidum 1 (5x107 CFU) in combination with Lactobacillus plantarum 8P-A3 (5x107 CFU) in the complex therapy of pneumonia caused by SARS-CoV-2 in adult patients without severe risk factors and their impact on health-related quality of life (QoL). Material and methods. An open, randomized prospective study included 100 patients (45 males, 55 females), aged from18 to 60 years without risk factors for severe COVID-19, with pneumonia confirmed by computed tomography and an area of lung lesion no more than 75% (moderate forms). SARS-CoV-2 RNA in nasal and oropharyngeal swabs (RT-PCR) was detected in 72% of the participants, in the rest it was highiy probable in terms of the aggregate parameters. The publication presents the results of self-assessment (94 respondents) of working capacity limitations, shortness of breath, intestinal disorders since the end of the probiotic regimen (PR hospitalization period - B. bifidum 1, 3 capsules 2 times a day for 10 days, then after hospitalization - B. bifidum 1 in combination with L. plantarum 8P-A3 2 powders 3 times a day for 14 days) and QoL (Short Form Medical Outcomes Study SF-36) 1 month after hospitalization. Results. At the end of PR, the ability to engage in daily activities was higher by 23.1% [95% confidence interval 5.3-37.3, OR 0.08 (0.08-0.77)]. Difficulty of breathing during exercise was less common by 29.7% [15.1-44.5%], OR 0.09 [0.02-0.40], hard stools and no bowel movements were recorded less often by 21.3% [8.5-34, 1] for 1-3 days. One month after hospitalization, the QoL of the patients receiving standard treatment was significantly reduced relative to population indicators in Russia. It was more significantly due to the psychological component of health [total measurement 38.1 (36.2-40.0)] and less significantly due to the physical component [49.5 (48.3-50.8)]. The main reasons limiting daily activities [Role Emotional (RE) 39.4 (37.4-41.4)] were decreased vitality [VT 40.2 (38.9-041.5)], emotional depression [Mental Health (MH) 41.2 (39.4-43.0)], deficit of social contacts [Social Functioning (SF) 45.1 (43.7-46.6)]. The patients who received PR had a higher ability to carry out daily activities [RE 57.7 (55.6-59.7)], the severity of psychological problems associated with fatigue, anxiety and depression was lower [MH 59.8 (58.7-60.9), p<0,001]. The effect of the PR on negative perceptions of social isolation was comparatively less [SF 53.9 (52.2-55.4)]. The QoL of the patients who additionally suffered from diarrhea in the acute period of SARS-CoV-2 pneumonia was worse in comparison with the patients without diarrhea (due to pain and inability to endure physical activity). The effects of immobilized (sorbed) probiotics to the QoL of the patients with diarrhea during the acute period of COVID-19 were most significant. Conclusion. PR had a significant positive effect on the QoL within a month after hospitalization, increasing working capacity and improving mental health, reducing the severity of psychological problems and fatigue. Additional researches are needed on the possible relationship of organic and functional gastrointestinal diseases with the progression of diarrhea in patients infected with SARS-CoV-2. No side effects of the sorbed probiotics regimen have been identified.Copyright © Eco-Vector, 2022.
bifidobacteria; Bifidobacterium bifidum 1; covid-19; health-related quality of life; immobilized probiotics; lactobacilli; Lactobacillus plantarum 8P-A3; long COVID; long-haulers; pneumonia; post-COVID-syndrome; postacute sequelae of SARS-CoV-2 (PASC) infection; sf-36; short-term outcomes of COVID-19; adult; anxiety; article; Bifidobacterium bifidum; computer assisted tomography; controlled study; coronavirus disease 2019/dt [Drug Therapy]; COVID-19 testing; daily life activity; depression; diarrhea; disease severity; drug efficacy; drug safety; dyspnea; enteropathy; exercise; fatigue; female; hard feces; hospitalization; human; Lactobacillus plantarum; lung lesion; major clinical study; male; nose smear; open study; oropharyngeal swab; priority journal; quality of life; randomized controlled trial; real time polymerase chain reaction; Russian Federation; self evaluation; Severe acute respiratory syndrome coronavirus 2; Short Form 36; social behavior; social interaction; social isolation; work capacity; probiotic agent/dt [Drug Therapy]; virus RNA/ec [Endogenous Compound]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
Russian
Journal:
Infectious Diseases: News, Opinions, Training
Year:
2022
Document Type:
Article
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