Incidence of thromboembolism in children with primary nephrotic syndrome: a systematic review and metaanalysis.
BMC Nephrol
; 24(1): 120, 2023 05 01.
Article
in English
| MEDLINE | ID: covidwho-2327007
ABSTRACT
OBJECTIVE:
To estimate the incidence of thromboembolism in children with primary nephrotic syndrome with Meta-analysis.METHODS:
Relevant studies published from January 1, 1980 to December 31, 2021 were retrieved from Pubmed, Web of science, Cochrane library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database(VIP) and Wangfang Database. Quality evaluation of the literatures included was conducted according to Agency for Healthcare Research and Quality(AHRQ) assessment tool, followed by data extraction and Meta-analysis with software RevMan 5.3.RESULTS:
A total of seven studies involving 3675 subjects were included. The overall prevalence was 4.9% with 95% CI of 2.83 to 7.05.However, a significant heterogeneity (P < 0.001) was observed with I2 = 89%. The prevalence of venous thromboembolism was 3.3% with 95% CI of 1.7 to 4.9. The prevalence of arterial thromboembolism was 0.5% with 95% CI of 0.2 to 1.4.CONCLUSION:
Children with nephrotic syndrome are prone to thromboembolism, and it may lead to disability or death, therefore prevention measures is critical to decreasing the prevalence of thromboembolism.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thromboembolism
/
Nephrotic Syndrome
Type of study:
Experimental Studies
/
Observational study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
BMC Nephrol
Journal subject:
Nephrology
Year:
2023
Document Type:
Article
Affiliation country:
S12882-023-03160-y
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