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Recovery of severely ill COVID-19 patients by intravenous immunoglobulin (IVIG) treatment: A case series.
Mohtadi, Negar; Ghaysouri, Abas; Shirazi, Samira; Shafiee, Elham; Bastani, Elham; Kokhazadeh, Taleb; Tavan, Hamed.
  • Mohtadi N; School of Medicine, Shahid Mostafa Khomaeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.
  • Ghaysouri A; Department of Internal Medicine, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
  • Shirazi S; Department of Cardiology, School of Medicine, Shahid Mostafa Khomaeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.
  • Sara Ansari; Department of Radiology, School of Medicine, Shahid Mostafa Khomaeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.
  • Shafiee E; Clinical Research Development Unit, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.
  • Bastani E; Department of Internal Medicine, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
  • Kokhazadeh T; Clinical Research Development Unit, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.
  • Tavan H; Clinical Research Development Unit, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran. Electronic address: hamedtavan@gmail.com.
Virology ; 548: 1-5, 2020 09.
Article in English | MEDLINE | ID: covidwho-361254
Semantic information from SemMedBD (by NLM)
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ABSTRACT

INTRODUCTION:

During the recent months, COVID-19 has turned to a global crisis claiming high mortality and morbidity among populations. Despite the high prevalence of the disease, it has currently no definitive treatment. We here reported the effects of intravenous immunoglobulin (IVIG) administration in severely ill COVID-19 patients diagnosed based on PCR and radiology tests. CASE PRESENTATION Five severely ill COVID-19 patients in whom standard treatments failed were administrated with IVIG which prevented the deterioration of clinical symptoms. All the patients were treated with high-dose IVIG (0.3-0.5 g/kg) for 5 consecutive days so that no patient would receive lower than 25 g of the drug. All the patients showed a desirable therapeutic response and were discharged from the hospital with a stable clinical condition after being recovered.

CONCLUSION:

Treatment with IVIG at the therapeutic dose of 0.3-0.5 g/kg can improve the clinical condition and O2 saturation and prevent the progression of pulmonary lesions in COVID-19 patients with severe symptoms in whom standard treatments have failed.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Immunoglobulins, Intravenous / Coronavirus Infections / Betacoronavirus Type of study: Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Virology Year: 2020 Document Type: Article Affiliation country: J.virol.2020.05.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Immunoglobulins, Intravenous / Coronavirus Infections / Betacoronavirus Type of study: Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Virology Year: 2020 Document Type: Article Affiliation country: J.virol.2020.05.006