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Type 3 hypersensitivity in COVID-19 vasculitis.
Roncati, Luca; Ligabue, Giulia; Fabbiani, Luca; Malagoli, Claudia; Gallo, Graziana; Lusenti, Beatrice; Nasillo, Vincenzo; Manenti, Antonio; Maiorana, Antonio.
  • Roncati L; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy; Hemolymphopathology Team, University Hospital of Modena, Modena, Italy; Immunohistochemistry Lab, University Hospital of Modena, Modena, Italy. Electronic address: roncati.luca@aou.mo.it.
  • Ligabue G; Nephrology Lab, University of Modena and Reggio Emilia, Modena, Italy.
  • Fabbiani L; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy; Immunohistochemistry Lab, University Hospital of Modena, Modena, Italy.
  • Malagoli C; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy; Immunohistochemistry Lab, University Hospital of Modena, Modena, Italy.
  • Gallo G; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy.
  • Lusenti B; Hemolymphopathology Team, University Hospital of Modena, Modena, Italy.
  • Nasillo V; Hemolymphopathology Team, University Hospital of Modena, Modena, Italy.
  • Manenti A; Department of Surgery, University of Modena and Reggio Emilia, Modena, Italy.
  • Maiorana A; Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy.
Clin Immunol ; 217: 108487, 2020 08.
Article in English | MEDLINE | ID: covidwho-436345
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Vasculitis / Immune Complex Diseases / Coronavirus Infections / Th2 Cells / Severe Acute Respiratory Syndrome / Betacoronavirus / Cytokine Release Syndrome Type of study: Case report Topics: Long Covid Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Vasculitis / Immune Complex Diseases / Coronavirus Infections / Th2 Cells / Severe Acute Respiratory Syndrome / Betacoronavirus / Cytokine Release Syndrome Type of study: Case report Topics: Long Covid Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article