Type 3 hypersensitivity in COVID-19 vasculitis.
Clin Immunol
; 217: 108487, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-436345
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Vasculitis
/
Immune Complex Diseases
/
Coronavirus Infections
/
Th2 Cells
/
Severe Acute Respiratory Syndrome
/
Betacoronavirus
/
Cytokine Release Syndrome
Type of study:
Case report
Topics:
Long Covid
Language:
English
Journal:
Clin Immunol
Journal subject:
Allergy and Immunology
Year:
2020
Document Type:
Article
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