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Cannabidiol Modulates Cytokine Storm in Acute Respiratory Distress Syndrome Induced by Simulated Viral Infection Using Synthetic RNA.
Khodadadi, Hesam; Salles, Évila Lopes; Jarrahi, Abbas; Chibane, Fairouz; Costigliola, Vincenzo; Yu, Jack C; Vaibhav, Kumar; Hess, David C; Dhandapani, Krishnan M; Baban, Babak.
  • Khodadadi H; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Salles ÉL; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta, Augusta University, Augusta, Georgia, USA.
  • Jarrahi A; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Chibane F; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta, Augusta University, Augusta, Georgia, USA.
  • Costigliola V; Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Yu JC; Department of Surgery, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Vaibhav K; European Medical Association (EMA), Brussels, Belgium.
  • Hess DC; Children's Hospital of Georgia, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Dhandapani KM; Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
  • Baban B; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Cannabis Cannabinoid Res ; 5(3): 197-201, 2020.
Article in English | MEDLINE | ID: covidwho-638503
Semantic information from SemMedBD (by NLM)
1. cannabidiol AFFECTS Storm NOS
Subject
cannabidiol
Predicate
AFFECTS
Object
Storm NOS
2. Virus Diseases CAUSES Respiratory Distress Syndrom
Subject
Virus Diseases
Predicate
CAUSES
Object
Respiratory Distress Syndrom
3. Storm NOS COEXISTS_WITH Respiratory Distress Syndrom
Subject
Storm NOS
Predicate
COEXISTS_WITH
Object
Respiratory Distress Syndrom
4. cannabidiol PREVENTS Storm NOS
Subject
cannabidiol
Predicate
PREVENTS
Object
Storm NOS
5. cannabidiol INHIBITS cytokine
Subject
cannabidiol
Predicate
INHIBITS
Object
cytokine
6. Body tissue PART_OF Lung
Subject
Body tissue
Predicate
PART_OF
Object
Lung
7. cannabidiol TREATS COVID-19
Subject
cannabidiol
Predicate
TREATS
Object
COVID-19
8. cannabidiol AFFECTS Storm NOS
Subject
cannabidiol
Predicate
AFFECTS
Object
Storm NOS
9. Virus Diseases CAUSES Respiratory Distress Syndrome, Adult
Subject
Virus Diseases
Predicate
CAUSES
Object
Respiratory Distress Syndrome, Adult
10. Storm NOS COEXISTS_WITH Respiratory Distress Syndrome, Adult
Subject
Storm NOS
Predicate
COEXISTS_WITH
Object
Respiratory Distress Syndrome, Adult
11. cannabidiol PREVENTS Storm NOS
Subject
cannabidiol
Predicate
PREVENTS
Object
Storm NOS
12. cannabidiol INHIBITS cytokine
Subject
cannabidiol
Predicate
INHIBITS
Object
cytokine
13. Body tissue PART_OF Lung
Subject
Body tissue
Predicate
PART_OF
Object
Lung
14. cannabidiol TREATS COVID-19
Subject
cannabidiol
Predicate
TREATS
Object
COVID-19
ABSTRACT

Introduction:

In the absence of effective antivirals and vaccination, the pandemic of COVID-19 remains the most significant challenge to our health care system in decades. There is an urgent need for definitive therapeutic intervention. Clinical reports indicate that the cytokine storm associated with acute respiratory distress syndrome (ARDS) is the leading cause of mortality in severe cases of some respiratory viral infections, including COVID-19. In recent years, cannabinoids have been investigated extensively due to their potential effects on the human body. Among all cannabinoids, cannabidiol (CBD) has demonstrated potent anti-inflammatory effects in a variety of pathological conditions. Therefore, it is logical to explore whether CBD can reduce the cytokine storm and treat ARDS. Materials and

Methods:

In this study, we show that intranasal application of Poly(IC), a synthetic analogue of viral double-stranded RNA, simulated symptoms of severe viral infections inducing signs of ARDS and cytokine storm.

Discussion:

The administration of CBD downregulated the level of proinflammatory cytokines and ameliorated the clinical symptoms of Poly IC-induced ARDS.

Conclusion:

Our results suggest a potential protective role for CBD during ARDS that may extend CBD as part of the treatment of COVID-19 by reducing the cytokine storm, protecting pulmonary tissues, and re-establishing inflammatory homeostasis.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Cannabis Cannabinoid Res Year: 2020 Document Type: Article Affiliation country: Can.2020.0043

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Cannabis Cannabinoid Res Year: 2020 Document Type: Article Affiliation country: Can.2020.0043