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Neurological consequences of COVID-19: what have we learned and where do we go from here?
Jarrahi, Abbas; Ahluwalia, Meenakshi; Khodadadi, Hesam; da Silva Lopes Salles, Evila; Kolhe, Ravindra; Hess, David C; Vale, Fernando; Kumar, Manish; Baban, Babak; Vaibhav, Kumar; Dhandapani, Krishnan M.
  • Jarrahi A; Department of Neurosurgery, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, Georgia.
  • Ahluwalia M; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, Georgia.
  • Khodadadi H; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia.
  • da Silva Lopes Salles E; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia.
  • Kolhe R; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, Georgia.
  • Hess DC; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, Georgia.
  • Vale F; Department of Neurosurgery, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, Georgia.
  • Kumar M; Department of Allied Health Science, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, Karnataka, India.
  • Baban B; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia.
  • Vaibhav K; Department of Neurosurgery, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, Georgia.
  • Dhandapani KM; Department of Neurosurgery, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, Georgia. kdhandapani@augusta.edu.
J Neuroinflammation ; 17(1): 286, 2020 Sep 30.
Article in English | MEDLINE | ID: covidwho-808484
Semantic information from SemMedBD (by NLM)
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ABSTRACT
The coronavirus disease-19 (COVID-19) pandemic is an unprecedented worldwide health crisis. COVID-19 is caused by SARS-CoV-2, a highly infectious pathogen that is genetically similar to SARS-CoV. Similar to other recent coronavirus outbreaks, including SARS and MERS, SARS-CoV-2 infected patients typically present with fever, dry cough, fatigue, and lower respiratory system dysfunction, including high rates of pneumonia and acute respiratory distress syndrome (ARDS); however, a rapidly accumulating set of clinical studies revealed atypical symptoms of COVID-19 that involve neurological signs, including headaches, anosmia, nausea, dysgeusia, damage to respiratory centers, and cerebral infarction. These unexpected findings may provide important clues regarding the pathological sequela of SARS-CoV-2 infection. Moreover, no efficacious therapies or vaccines are currently available, complicating the clinical management of COVID-19 patients and emphasizing the public health need for controlled, hypothesis-driven experimental studies to provide a framework for therapeutic development. In this mini-review, we summarize the current body of literature regarding the central nervous system (CNS) effects of SARS-CoV-2 and discuss several potential targets for therapeutic development to reduce neurological consequences in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Nervous System Diseases Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Neuroinflammation Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: S12974-020-01957-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Nervous System Diseases Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Neuroinflammation Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: S12974-020-01957-4