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Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome.
Salles, Évila Lopes; Khodadadi, Hesam; Jarrahi, Abbas; Ahluwalia, Meenakshi; Paffaro, Valdemar Antonio; Costigliola, Vincenzo; Yu, Jack C; Hess, David C; Dhandapani, Krishnan M; Baban, Babak.
  • Salles ÉL; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, University, Augusta, GA, USA.
  • Khodadadi H; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta University, Augusta, GA, USA.
  • Jarrahi A; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, University, Augusta, GA, USA.
  • Ahluwalia M; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta University, Augusta, GA, USA.
  • Paffaro VA; Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Costigliola V; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Yu JC; Department for Cell and Developmental Biology, Institute of Biomedical Sciences -Federal, University of Alfenas, Alfenas, Brazil.
  • Hess DC; European Medical Association (EMA), Brussels, Belgium.
  • Dhandapani KM; Children's Hospital of Georgia and Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Baban B; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
J Cell Mol Med ; 24(21): 12869-12872, 2020 11.
Article in English | MEDLINE | ID: covidwho-863121
Semantic information from SemMedBD (by NLM)
1. cannabidiol INTERACTS_WITH APLN gene|APLN
Subject
cannabidiol
Predicate
INTERACTS_WITH
Object
APLN gene|APLN
2. APLN gene|APLN ASSOCIATED_WITH Respiratory Distress Syndrom
Subject
APLN gene|APLN
Predicate
ASSOCIATED_WITH
Object
Respiratory Distress Syndrom
3. Vaccination TREATS COVID-19
Subject
Vaccination
Predicate
TREATS
Object
COVID-19
4. cannabidiol TREATS Symptoms
Subject
cannabidiol
Predicate
TREATS
Object
Symptoms
5. Peptides STIMULATES APLN gene|APLN
Subject
Peptides
Predicate
STIMULATES
Object
APLN gene|APLN
6. Peptides TREATS Respiratory Distress Syndrom
Subject
Peptides
Predicate
TREATS
Object
Respiratory Distress Syndrom
7. cannabidiol AFFECTS Immune response
Subject
cannabidiol
Predicate
AFFECTS
Object
Immune response
8. Blood LOCATION_OF APLN gene|APLN
Subject
Blood
Predicate
LOCATION_OF
Object
APLN gene|APLN
9. Structure of parenchyma of lung LOCATION_OF APLN gene|APLN
Subject
Structure of parenchyma of lung
Predicate
LOCATION_OF
Object
APLN gene|APLN
10. cannabidiol TREATS Inflammatory disorder
Subject
cannabidiol
Predicate
TREATS
Object
Inflammatory disorder
11. cannabidiol INTERACTS_WITH APLN gene|APLN
Subject
cannabidiol
Predicate
INTERACTS_WITH
Object
APLN gene|APLN
12. APLN gene|APLN ASSOCIATED_WITH Respiratory Distress Syndrome, Adult
Subject
APLN gene|APLN
Predicate
ASSOCIATED_WITH
Object
Respiratory Distress Syndrome, Adult
13. Vaccination TREATS COVID-19
Subject
Vaccination
Predicate
TREATS
Object
COVID-19
14. cannabidiol TREATS Symptoms
Subject
cannabidiol
Predicate
TREATS
Object
Symptoms
15. Peptides STIMULATES APLN gene|APLN
Subject
Peptides
Predicate
STIMULATES
Object
APLN gene|APLN
16. Peptides TREATS Respiratory Distress Syndrome, Adult
Subject
Peptides
Predicate
TREATS
Object
Respiratory Distress Syndrome, Adult
17. cannabidiol AFFECTS Immune response
Subject
cannabidiol
Predicate
AFFECTS
Object
Immune response
18. Blood LOCATION_OF APLN gene|APLN
Subject
Blood
Predicate
LOCATION_OF
Object
APLN gene|APLN
19. Structure of parenchyma of lung LOCATION_OF APLN gene|APLN
Subject
Structure of parenchyma of lung
Predicate
LOCATION_OF
Object
APLN gene|APLN
20. cannabidiol TREATS Inflammatory disorder
Subject
cannabidiol
Predicate
TREATS
Object
Inflammatory disorder
ABSTRACT
Considering lack of target-specific antiviral treatment and vaccination for COVID-19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID-19-infected patient outcomes. In a follow-up study to our recent findings indicating the potential of Cannabidiol (CBD) in the treatment of acute respiratory distress syndrome (ARDS), here we show for the first time that CBD may ameliorate the symptoms of ARDS through up-regulation of apelin, a peptide with significant role in the central and peripheral regulation of immunity, CNS, metabolic and cardiovascular system. By administering intranasal Poly (IC), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues. CBD treatment was able to reverse the symptoms of ARDS towards a normal level. Importantly, CBD treatment increased the apelin expression significantly, suggesting a potential crosstalk between apelinergic system and CBD may be the therapeutic target in the treatment of inflammatory diseases such as COVID-19 and many other pathologic conditions.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Cannabidiol / Apelin Type of study: Cohort study / Prognostic study Topics: Vaccines Limits: Animals Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Jcmm.15883

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Cannabidiol / Apelin Type of study: Cohort study / Prognostic study Topics: Vaccines Limits: Animals Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Jcmm.15883