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COVID-19 pathophysiology: A review.
Yuki, Koichi; Fujiogi, Miho; Koutsogiannaki, Sophia.
  • Yuki K; Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Department of Anaesthesia, Harvard Medical School, United States of America. Electronic address: koichi.yuki@childrens.harvard.edu.
  • Fujiogi M; Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Department of Anaesthesia, Harvard Medical School, United States of America. Electronic address: miho.fujiogi@childrens.harvard.edu.
  • Koutsogiannaki S; Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Department of Anaesthesia, Harvard Medical School, United States of America. Electronic address: Sophia.koutsogiannaki@childrens.harvard.edu.
Clin Immunol ; 215: 108427, 2020 06.
Article in English | MEDLINE | ID: covidwho-88544
ABSTRACT
In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused by this virus was termed COVID-19. The virus is transmittable between humans and has caused pandemic worldwide. The number of death tolls continues to rise and a large number of countries have been forced to do social distancing and lockdown. Lack of targeted therapy continues to be a problem. Epidemiological studies showed that elder patients were more susceptible to severe diseases, while children tend to have milder symptoms. Here we reviewed the current knowledge about this disease and considered the potential explanation of the different symptomatology between children and adults.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus Type of study: Observational study Limits: Aged / Animals / Child / Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus Type of study: Observational study Limits: Aged / Animals / Child / Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article