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Ivermectin: An Anthelmintic, an Insecticide, and Much More.
Martin, Richard J; Robertson, Alan P; Choudhary, Shivani.
  • Martin RJ; Department of Biomedical Science, Iowa State University, Ames, IA 50011, USA. Electronic address: rjmartin@iastate.edu.
  • Robertson AP; Department of Biomedical Science, Iowa State University, Ames, IA 50011, USA.
  • Choudhary S; Department of Biomedical Science, Iowa State University, Ames, IA 50011, USA.
Trends Parasitol ; 37(1): 48-64, 2021 01.
Article in English | MEDLINE | ID: covidwho-943553
ABSTRACT
Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and recent studies that have sought to reposition ivermectin for the treatment of other diseases that are not caused by helminth and insect parasites. The standard theory of its anthelmintic and insecticidal mode of action is that it is a selective positive allosteric modulator of glutamate-gated chloride channels found in nematodes and insects. At higher concentrations, ivermectin also acts as an allosteric modulator of ion channels found in host central nervous systems. In addition, in tissue culture, at concentrations higher than anthelmintic concentrations, ivermectin shows antiviral, antimalarial, antimetabolic, and anticancer effects. Caution is required before extrapolating from these preliminary repositioning experiments to clinical use, particularly for Covid-19 treatment, because of the high concentrations of ivermectin used in tissue-culture experiments.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ivermectin / Insecticides / Anthelmintics Type of study: Prognostic study Limits: Animals Language: English Journal: Trends Parasitol Journal subject: Parasitology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ivermectin / Insecticides / Anthelmintics Type of study: Prognostic study Limits: Animals Language: English Journal: Trends Parasitol Journal subject: Parasitology Year: 2021 Document Type: Article