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Could Cannabidiol Be a Treatment for Coronavirus Disease-19-Related Anxiety Disorders?
O'Sullivan, Saoirse E; Stevenson, Carl W; Laviolette, Steven R.
  • O'Sullivan SE; Artelo Biosciences, San Diego, California, USA.
  • Stevenson CW; School of Biosciences, University of Nottingham, Loughborough, United Kingdom.
  • Laviolette SR; Department of Anatomy and Cell Biology and Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
Cannabis Cannabinoid Res ; 6(1): 7-18, 2021.
Article in English | MEDLINE | ID: covidwho-955809
Semantic information from SemMedBD (by NLM)
1. cannabidiol TREATS Anxiety Disorders
Subject
cannabidiol
Predicate
TREATS
Object
Anxiety Disorders
2. Anti-Anxiety Agents TREATS Anxiety Disorders
Subject
Anti-Anxiety Agents
Predicate
TREATS
Object
Anxiety Disorders
3. cannabidiol ADMINISTERED_TO Persons
Subject
cannabidiol
Predicate
ADMINISTERED_TO
Object
Persons
4. Disease PROCESS_OF Persons
Subject
Disease
Predicate
PROCESS_OF
Object
Persons
5. Parkinson Disease PROCESS_OF Patients
Subject
Parkinson Disease
Predicate
PROCESS_OF
Object
Patients
6. cannabidiol PREVENTS Anxiety
Subject
cannabidiol
Predicate
PREVENTS
Object
Anxiety
7. Anxiety PROCESS_OF Healthy Volunteers
Subject
Anxiety
Predicate
PROCESS_OF
Object
Healthy Volunteers
8. Phobi PROCESS_OF C0030705
Subject
Phobi
Predicate
PROCESS_OF
Object
C0030705
9. Psychotic Disorders PROCESS_OF Patients
Subject
Psychotic Disorders
Predicate
PROCESS_OF
Object
Patients
10. Psychotic Disorders PROCESS_OF Persons
Subject
Psychotic Disorders
Predicate
PROCESS_OF
Object
Persons
11. Anxiety PROCESS_OF Patients
Subject
Anxiety
Predicate
PROCESS_OF
Object
Patients
12. Crohn Disease PROCESS_OF Patients
Subject
Crohn Disease
Predicate
PROCESS_OF
Object
Patients
13. Depressive disorder PROCESS_OF Patients
Subject
Depressive disorder
Predicate
PROCESS_OF
Object
Patients
14. Post-Traumatic Stress Disorder PROCESS_OF Patients
Subject
Post-Traumatic Stress Disorder
Predicate
PROCESS_OF
Object
Patients
15. Sleep Disorders PROCESS_OF Patients
Subject
Sleep Disorders
Predicate
PROCESS_OF
Object
Patients
16. cannabidiol TREATS Anxiety Disorders
Subject
cannabidiol
Predicate
TREATS
Object
Anxiety Disorders
17. Anti-Anxiety Agents TREATS Anxiety Disorders
Subject
Anti-Anxiety Agents
Predicate
TREATS
Object
Anxiety Disorders
18. cannabidiol ADMINISTERED_TO Persons
Subject
cannabidiol
Predicate
ADMINISTERED_TO
Object
Persons
19. Disease PROCESS_OF Persons
Subject
Disease
Predicate
PROCESS_OF
Object
Persons
20. Parkinson Disease PROCESS_OF Patients
Subject
Parkinson Disease
Predicate
PROCESS_OF
Object
Patients
21. cannabidiol PREVENTS Anxiety
Subject
cannabidiol
Predicate
PREVENTS
Object
Anxiety
22. Anxiety PROCESS_OF Healthy Volunteers
Subject
Anxiety
Predicate
PROCESS_OF
Object
Healthy Volunteers
23. Phobia, Social PROCESS_OF Patients
Subject
Phobia, Social
Predicate
PROCESS_OF
Object
Patients
24. Psychotic Disorders PROCESS_OF Patients
Subject
Psychotic Disorders
Predicate
PROCESS_OF
Object
Patients
25. Psychotic Disorders PROCESS_OF Persons
Subject
Psychotic Disorders
Predicate
PROCESS_OF
Object
Persons
26. Anxiety PROCESS_OF Patients
Subject
Anxiety
Predicate
PROCESS_OF
Object
Patients
27. Crohn Disease PROCESS_OF Patients
Subject
Crohn Disease
Predicate
PROCESS_OF
Object
Patients
28. Depressive disorder PROCESS_OF Patients
Subject
Depressive disorder
Predicate
PROCESS_OF
Object
Patients
29. Post-Traumatic Stress Disorder PROCESS_OF Patients
Subject
Post-Traumatic Stress Disorder
Predicate
PROCESS_OF
Object
Patients
30. Sleep Disorders PROCESS_OF Patients
Subject
Sleep Disorders
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Coronavirus disease-19 (COVID-19)-related anxiety and post-traumatic stress symptoms (PTSS) or post-traumatic stress disorder (PTSD) are likely to be a significant long-term issue emerging from the current pandemic. We hypothesize that cannabidiol (CBD), a chemical isolated from Cannabis sativa with reported anxiolytic properties, could be a therapeutic option for the treatment of COVID-19-related anxiety disorders. In the global over-the-counter CBD market, anxiety, stress, depression, and sleep disorders are consistently the top reasons people use CBD. In small randomized controlled clinical trials, CBD (300-800 mg) reduces anxiety in healthy volunteers, patients with social anxiety disorder, those at clinical high risk of psychosis, in patients with Parkinson's disease, and in individuals with heroin use disorder. Observational studies and case reports support these findings, extending to patients with anxiety and sleep disorders, Crohn's disease, depression, and in PTSD. Larger ongoing trials in this area continue to add to this evidence base with relevant patient cohorts, sample sizes, and clinical end-points. Pre-clinical studies reveal the molecular targets of CBD in these indications as the cannabinoid receptor type 1 and cannabinoid receptor type 2 (mainly in fear memory processing), serotonin 1A receptor (mainly in anxiolysis) and peroxisome proliferator-activated receptor gamma (mainly in the underpinning anti-inflammatory/antioxidant effects). Observational and pre-clinical data also support CBD's therapeutic value in improving sleep (increased sleep duration/quality and reduction in nightmares) and depression, which are often comorbid with anxiety. Together these features of CBD make it an attractive novel therapeutic option in COVID-related PTSS that merits investigation and testing through appropriately designed randomized controlled trials.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety Disorders / Cannabidiol / Cannabinoid Receptor Modulators / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Cannabis Cannabinoid Res Year: 2021 Document Type: Article Affiliation country: Can.2020.0102

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety Disorders / Cannabidiol / Cannabinoid Receptor Modulators / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Cannabis Cannabinoid Res Year: 2021 Document Type: Article Affiliation country: Can.2020.0102