Clinical Observation of the Rehabilitation Formula for Banking up Earth to Generate Metal in Treating COVID-19 Patients with Deficiency of Lung and Spleen Syndrome in the Recovery Stage / 扶土生金康复方治疗COVID-19恢复期肺脾不足证患者临床观察

ABSTRACT

OBJECTIVE To discuss the influence of the rehabilitation formula for banking up earth to generate metal onCO-VID-19 patients with deficiency of lung and spleen syndrome in the recovery stage in terms of clinical efficacy and immunology related indexes. METHODS 120 COVID-19 patients with deficiency of lung and spleen syndrome in the recovery stage were divided into the treatment group (89 cases) and the control group (31 cases). The rehabilitation formula for banking up earth divided into the treatment group case to generate metal was given to the treatment group while the control group was not given any interventions. The course was 14 days. The symptom scores were observed before and after treatment in the two groups and the effective rates in the two groups were compared. RESULTS The effective rate of the treatment group was 94.38%, higher than 54. 84% in the control group (P<0.01).The symptom scores before and after treatment in group A and в had no significant differences (P> 0.05), and so did the effective rate (P>0.05). The levels of IgA, Complement C3 after the treatment group were lower than those before treatment (P<0.01). The percent ages of CD3, CD4 and CD8 were higher after the treatment group than those before (P <0.01). Compared with those in the control group, the percentages of CD3 and CD4 in the treatment group had significant difference (P<0.05). CONCLUSION The rehabilitation formula for banking up earth to generate metal can effectively improve the clinical symptoms caused by deficiency of lung and spleen for COVID-19 patients in the recovery stage as well as their immunologic function.

摘要

目的 观察扶土生金康复方治疗新型冠状病毒肺炎（COVID-19）恢复期肺脾不足证患者的中医证候疗效及对免疫学等相关指标的影响。方法 将120例COVID-19恢复期肺脾不足证患者分为治疗组89例和对照组31例，治疗组给予扶土生金康复方治疗，对照组无任何干预措施，疗程为14d。观察2组治疗前后中医证候积分变化情况，并比较2组总有效率。观察2组治疗前后体液免疫和T淋巴细胞亚群相关指标变化情况。结果 治疗后治疗组中医证候积分总有效率为94.38%，高于对照组54.84%(P<0.01)。治疗组IgA、补体C3水平明显降低(P<0.01),IgG、IgM水平明显升高（P<0.05），与对照组比较，IgM、补体C3水平有显著性差异（P<0.05～0.01）。治疗组CD3、CD4、CD8百分比明显升高（P<0.01），与对照组比较，CD3、CD4百分比有显著性差异（P<0.05）。结论 扶土生金康复方能够有效改善COVID-19恢复期肺脾不足证患者的中医临床症状，并且能较好地改善患者免疫功能。