Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection.
J Infect Dis
; 223(9): 1522-1527, 2021 05 20.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1238204
ABSTRACT
BACKGROUND:
Guidelines for stopping coronavirus disease 2019 patient isolation are mainly symptom-based, with isolation for 10 to 20 days depending on their condition.METHODS:
In this study, we describe 3 deeply immunocompromised patients, each with different clinical evolutions. We observed (1) the patients' epidemiological, clinical, and serological data, (2) infectiousness using viral culture, and (3) viral mutations accumulated over time.RESULTS:
Asymptomatic carriage, symptom resolution, or superinfection with a second severe acute respiratory syndrome coronavirus 2 strain were observed, all leading to prolonged infectious viral shedding for several months.CONCLUSIONS:
Understanding underlying mechanisms and frequency of prolonged infectiousness is crucial to adapt current guidelines and strengthen the use of systematic polymerase chain reaction testing before stopping isolation in immunocompromised populations.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Superinfecção
/
Hospedeiro Imunocomprometido
/
Eliminação de Partículas Virais
/
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Relato de caso
/
Estudo diagnóstico
/
Estudo prognóstico
/
Revisão sistemática/Meta-análise
Tópicos:
Covid persistente
Limite:
Adulto
/
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J Infect Dis
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Infdis
Similares
MEDLINE
...
LILACS
LIS