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Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection.
Tarhini, Hassan; Recoing, Amélie; Bridier-Nahmias, Antoine; Rahi, Mayda; Lambert, Céleste; Martres, Pascale; Lucet, Jean-Christophe; Rioux, Christophe; Bouzid, Donia; Lebourgeois, Samuel; Descamps, Diane; Yazdanpanah, Yazdan; Le Hingrat, Quentin; Lescure, François-Xavier; Visseaux, Benoit.
  • Tarhini H; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
  • Recoing A; Laboratoire de Virologie, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
  • Bridier-Nahmias A; Université de Paris, Infection Modelisation Antimicrobial Evolution (IAME), Inserm UMR1137, Paris, France.
  • Rahi M; Université de Paris, Infection Modelisation Antimicrobial Evolution (IAME), Inserm UMR1137, Paris, France.
  • Lambert C; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
  • Martres P; Unité d'Aval des Urgences, Centre Hospitalier René Dubos, Cergy Pontoise, France.
  • Lucet JC; Microbiologie, Centre Hospitalier René Dubos, Cergy Pontoise, France.
  • Rioux C; Université de Paris, Infection Modelisation Antimicrobial Evolution (IAME), Inserm UMR1137, Paris, France.
  • Bouzid D; Equipe de Prévention du Risque Infectieux, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
  • Lebourgeois S; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
  • Descamps D; Université de Paris, Infection Modelisation Antimicrobial Evolution (IAME), Inserm UMR1137, Paris, France.
  • Yazdanpanah Y; Service d'Accueil des Urgences, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
  • Le Hingrat Q; Laboratoire de Virologie, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
  • Lescure FX; Université de Paris, Infection Modelisation Antimicrobial Evolution (IAME), Inserm UMR1137, Paris, France.
  • Visseaux B; Laboratoire de Virologie, Hôpital Bichat Claude Bernard, AP-HP, Paris, France.
J Infect Dis ; 223(9): 1522-1527, 2021 05 20.
Artigo em Inglês | MEDLINE | ID: covidwho-1238204
Informação semântica de SemMedBD (por NLM)
1. Isolation procedure USES Stop brand of fluoride
Sujeito
Isolation procedure
Predicado
USES
Objeto
Stop brand of fluoride
2. Isolation procedure USES Stop brand of fluoride
Sujeito
Isolation procedure
Predicado
USES
Objeto
Stop brand of fluoride
ABSTRACT

BACKGROUND:

Guidelines for stopping coronavirus disease 2019 patient isolation are mainly symptom-based, with isolation for 10 to 20 days depending on their condition.

METHODS:

In this study, we describe 3 deeply immunocompromised patients, each with different clinical evolutions. We observed (1) the patients' epidemiological, clinical, and serological data, (2) infectiousness using viral culture, and (3) viral mutations accumulated over time.

RESULTS:

Asymptomatic carriage, symptom resolution, or superinfection with a second severe acute respiratory syndrome coronavirus 2 strain were observed, all leading to prolonged infectious viral shedding for several months.

CONCLUSIONS:

Understanding underlying mechanisms and frequency of prolonged infectiousness is crucial to adapt current guidelines and strengthen the use of systematic polymerase chain reaction testing before stopping isolation in immunocompromised populations.
Assuntos
Palavras-chave

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Superinfecção / Hospedeiro Imunocomprometido / Eliminação de Partículas Virais / SARS-CoV-2 / COVID-19 Tipo de estudo: Relato de caso / Estudo diagnóstico / Estudo prognóstico / Revisão sistemática/Meta-análise Tópicos: Covid persistente Limite: Adulto / Idoso / Humanos / Masculino Idioma: Inglês Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Infdis

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Superinfecção / Hospedeiro Imunocomprometido / Eliminação de Partículas Virais / SARS-CoV-2 / COVID-19 Tipo de estudo: Relato de caso / Estudo diagnóstico / Estudo prognóstico / Revisão sistemática/Meta-análise Tópicos: Covid persistente Limite: Adulto / Idoso / Humanos / Masculino Idioma: Inglês Revista: J Infect Dis Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Infdis