Manifestations and impact of the COVID-19 pandemic in neuroinflammatory diseases.
Ann Clin Transl Neurol
; 8(4): 918-928, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1092494
ABSTRACT
OBJECTIVE:
To report initial results of a planned multicenter year-long prospective study examining the risk and impact of COVID-19 among persons with neuroinflammatory disorders (NID), particularly multiple sclerosis (MS).METHODS:
In April 2020, we deployed online questionnaires to individuals in their home environment to assess the prevalence and potential risk factors of suspected COVID-19 in persons with NID (PwNID) and change in their neurological care.RESULTS:
Our cohort included 1115 participants (630 NID, 98% MS; 485 reference) as of 30 April 2020. 202 (18%) participants, residing in areas with high COVID-19 case prevalence, met the April 2020 CDC symptom criteria for suspected COVID-19, but only 4% of all participants received testing given testing shortages. Among all participants, those with suspected COVID-19 were younger, more racially diverse, and reported more depression and liver disease. PwNID had the same rate of suspected COVID-19 as the reference group. Early changes in disease management included telemedicine visits in 21% and treatment changes in 9% of PwNID. After adjusting for potential confounders, increasing neurological disability was associated with a greater likelihood of suspected COVID-19 (ORadj = 1.45, 1.17-1.84). INTERPRETATIONS Our study of real-time, patient-reported experience during the COVID-19 pandemic complements physician-reported MS case registries which capture an excess of severe cases. Overall, PwNID seem to have a risk of suspected COVID-19 similar to the reference population.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes do Sistema Nervoso
/
Autorrelato
/
COVID-19
Tipo de estudo:
Estudo de coorte
/
Estudo diagnóstico
/
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
/
Pesquisa qualitativa
Tópicos:
Covid persistente
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
/
Meia-Idade
Idioma:
Inglês
Revista:
Ann Clin Transl Neurol
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Acn3.51314
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