Vaccines: Underlying Principles of Design and Testing.
Clin Pharmacol Ther
; 109(4): 987-999, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1126363
ABSTRACT
In this paper, we review the key elements that should be considered to take a novel vaccine from the laboratory through to licensure in the modern era. This paper is divided into four sections. First, we discuss the host immune responses that we engage with vaccines. Second, we discuss how in vivo and in vitro studies can inform vaccine design. Third, we discuss different vaccine modalities that have been licensed or are in testing in humans. Last, we overview the basic principles of vaccine approvals. Throughout we provide real-world examples of vaccine development against infectious diseases, including coronavirus disease 2019 (COVID-19).
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Vacinas
/
Aprovação de Drogas
Tipo de estudo:
Estudo prognóstico
Tópicos:
Medicina tradicional
/
Vacinas
País/Região como assunto:
América do Norte
Idioma:
Inglês
Revista:
Clin Pharmacol Ther
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Cpt.2207
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