SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium.
Cell Stem Cell
; 28(7): 1205-1220.e7, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1230788
ABSTRACT
The SARS-CoV-2 pandemic has caused unparalleled disruption of global behavior and significant loss of life. To minimize SARS-CoV-2 spread, understanding the mechanisms of infection from all possible routes of entry is essential. While aerosol transmission is thought to be the primary route of spread, viral particles have been detected in ocular fluid, suggesting that the eye may be a vulnerable point of viral entry. To this end, we confirmed SARS-CoV-2 entry factor and antigen expression in post-mortem COVID-19 patient ocular surface tissue and observed productive viral replication in cadaver samples and eye organoid cultures, most notably in limbal regions. Transcriptional analysis of ex vivo infected ocular surface cells and hESC-derived eye cultures revealed robust induction of NF-κB in infected cells as well as diminished type I/III interferon signaling. Together these data suggest that the eye can be directly infected by SARS-CoV-2 and implicate limbus as a portal for viral entry.
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Texto completo:
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Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Embrionárias Humanas
/
COVID-19
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Cell Stem Cell
Ano de publicação:
2021
Tipo de documento:
Artigo
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