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Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome.
Shin, Chong-Hyun; Kim, Ki-Hye; Jeeva, Subbiah; Kang, Sang-Moo.
  • Shin CH; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Kim KH; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Jeeva S; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
  • Kang SM; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Cells ; 10(6)2021 06 06.
Artigo em Inglês | MEDLINE | ID: covidwho-1259430
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease 2019 (COVID-19) pandemic. A strong correlation has been demonstrated between worse COVID-19 outcomes, aging, and metabolic syndrome (MetS), which is primarily derived from obesity-induced systemic chronic low-grade inflammation with numerous complications, including type 2 diabetes mellitus (T2DM). The majority of COVID-19 deaths occurs in people over the age of 65. Individuals with MetS are inclined to manifest adverse disease consequences and mortality from COVID-19. In this review, we examine the prevalence and molecular mechanisms underlying enhanced risk of COVID-19 in elderly people and individuals with MetS. Subsequently, we discuss current progresses in treating COVID-19, including the development of new COVID-19 vaccines and antivirals, towards goals to elaborate prophylactic and therapeutic treatment options in this vulnerable population.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Envelhecimento / Quimioprevenção / Síndrome Metabólica / COVID-19 Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Ensaios controlados aleatorizados Tópicos: Covid persistente / Vacinas Limite: Humanos Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Cells10061412

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Envelhecimento / Quimioprevenção / Síndrome Metabólica / COVID-19 Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Ensaios controlados aleatorizados Tópicos: Covid persistente / Vacinas Limite: Humanos Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Cells10061412