Association of Preexisting Asthma and Other Allergic Diseases With Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis.
Front Med (Lausanne)
; 8: 670744, 2021.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1305652
ABSTRACT
Background:
Respiratory viruses are known to contribute to asthma exacerbations. A meta-analysis of three studies reported no association between coronavirus disease 2019 (COVID-19) mortality and preexisting asthma. This study aimed to investigate the mortality of patients with COVID-19 in relation to preexisting asthma and other allergic diseases associated with changes in respiratory function.Methods:
PubMed, Embase, and the Cochrane Library were queried for papers published up to April 9, 2021 (1) population patients who tested positive for SARS-CoV-2 according to the WHO guidelines; (2) exposure preexisting asthma or allergic rhinitis; (3)outcomes:
mortality, ICU admission, and/or hospitalization; and (4) language English. For studies that reported adjusted models, the most adjusted model was used for this meta-analysis; otherwise, unadjusted results were used.Results:
Twenty-four studies (1,169,441 patients) were included in this meta-analysis. Patients who died of COVID-19 were not more likely to have preexisting asthma (OR = 0.95, 95%CI 0.78-1.15, P = 0.602; I2 = 63.5%, Pheterogeneity < 0.001). Patients with COVID-19 and admitted to the ICU (OR = 1.17, 95%CI 0.81-1.68, P = 0.407; I2 = 91.1%, Pheterogeneity = 0.407), or hospitalized (OR = 0.91, 95%CI 0.76-1.10, P = 0.338; I2 = 79.1%, Pheterogeneity < 0.001) were not more likely to have preexisting asthma. The results for mortality and hospitalization remained non-significant when considering the adjusted and unadjusted models separately. The results from the sensitivity analyses were consistent with the primary analyses, suggesting the robustness of our results.Conclusion:
This meta-analysis suggests that the patients who died from COVID-19, were admitted to the ICU, or hospitalized were not more likely to have asthma.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Tipo de estudo:
Revisões
/
Revisão sistemática/Meta-análise
Idioma:
Inglês
Revista:
Front Med (Lausanne)
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Fmed.2021.670744
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