Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U.S. Black women.
PLoS One
; 16(7): e0255132, 2021.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1327980
ABSTRACT
OBJECTIVE:
Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection. Black women commonly experience 25(OH)D insufficiency and are overrepresented among COVID-19 cases. We conducted a prospective analysis of serum 25(OH)D levels in relation to COVID-19 infection among participants in the Black Women's Health Study.METHODS:
Since 1995, the Black Women's Health Study has followed 59,000 U.S. Black women through biennial mailed or online questionnaires. Over 13,000 study participants provided a blood sample in 2013-2017. 25(OH)D assays were performed in a certified national laboratory shortly after collection of the samples. In 2020, participants who had completed the online version of the 2019 biennial health questionnaire were invited to complete a supplemental online questionnaire assessing their experiences related to the COVID-19 pandemic, including whether they had been tested for COVID-19 infection and the result of the test. We used logistic regression analysis to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of 25(OH)D level with COVID-19 positivity, adjusting for age, number of people living in the household, neighborhood socioeconomic status, and other potential confounders.RESULTS:
Among 5,081 eligible participants whose blood sample had been assayed for 25(OH)D, 1,974 reported having had a COVID-19 test in 2020. Relative to women with 25(OH)D levels of 30 ng/mL (75 nmol/l) or more, multivariable-adjusted ORs for COVID-19 infection in women with levels of 20-29 ng/mL (50-72.5 nmol/l) and <20 ng/mL (<50 nmol/l) were, respectively, 1.48 (95% CI 0.95-2.30) and 1.69 (95% CI 1.04-2.72) (p trend 0.02).CONCLUSION:
The present results suggest that U.S. Black women with lower levels of 25(OH)D are at increased risk of infection with COVID-19. Further work is needed to confirm these findings and determine the optimal level of 25(OH)D for a beneficial effect.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Negro ou Afro-Americano
/
COVID-19
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Pesquisa qualitativa
Limite:
Adulto
/
Feminino
/
Humanos
/
Meia-Idade
País/Região como assunto:
América do Norte
Idioma:
Inglês
Revista:
PLoS One
Assunto da revista:
Ciência
/
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Journal.pone.0255132
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