Predictive Value of Neutrophil/Lymphocyte Ratio (NLR) on Cardiovascular Events in Patients with COVID-19.
Int J Gen Med
; 14: 3899-3907, 2021.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1337596
ABSTRACT
BACKGROUND:
The research on the association between coronavirus disease 2019 (COVID-19) and cardiovascular disease (CVD) is still insufficient.AIM:
This study aimed to investigate the association between neutrophil/lymphocyte ratio (NLR) and risk of cardiovascular events in patients with COVID-19.METHODS:
Our study included 159 patients with COVID-19 who were measured for NLR value within the first 24 hours of admission. They were followed up for 6 months after discharge and then the relationship between levels of NLR and risk of cardiovascular events was assessed.RESULTS:
In all included patients with COVID-19, NLR values in patients with cardiovascular events [16.28 (4.95-45.18)] were significantly higher than patients without cardiovascular events [4.75 (2.60-7.47)]. A multivariate logistic regression model revealed that elevated NLR value [increased per SD, 2.41 (1.43-4.29), P<0.001; increased 1 of NLR, 2.05 (1.33-4.01), P=0.010] was significantly and independently associated with increased risk of CVD history on admission after adjustment of related confounding factors. Then, Cox regression analysis revealed that elevated NLR value had a significant association with increased risk of cardiovascular events [increased per SD, 2.36 (1.42-4.36), P<0.001; Increased 1 of NLR, 2.00 (1.30-3.97), P=0.014] after adjustments of these same confounding factors. Furthermore, the ROC curve suggested that NLR value (AUC=0.803, 95% CI=0.731-0.875, P<0.001, sensitivity 81.2%, and specificity 82.6%) has a good predictive value for cardiovascular events during follow-up.CONCLUSION:
High NLR value was clinically associated with elevated risk of cardiovascular events in patients with COVID-19, which might be a potential biomarker for predicting cardiovascular events in the current COVID-19 pandemic.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Tipo de estudo:
Estudo de coorte
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Int J Gen Med
Ano de publicação:
2021
Tipo de documento:
Artigo
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