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Age-related risk factors and severity of SARS-CoV-2 infection: a systematic review and meta-analysis.
Rahman, Mohammad Meshbahur; Bhattacharjee, Badhan; Farhana, Zaki; Hamiduzzaman, Mohammad; Chowdhury, Muhammad Abdul Baker; Hossain, Mohammad Sorowar; Siddiqee, Mahbubul H; Islam, Md Ziaul; Raheem, Enayetur; Uddin, Md Jamal.
  • Rahman MM; Biomedical Research Foundation, Dhaka, Bangladesh.
  • Bhattacharjee B; Department of Biotechnology, BRAC University, Dhaka, Bangladesh.
  • Farhana Z; Department of Community Medicine, National Institute of Preventive and Social Medicine, Mohakhali, Dhaka, Bangladesh.
  • Hamiduzzaman M; College of Health, Medicine & Wellbeing, University of Newcastle, New South Wales, Australia.
  • Chowdhury MAB; Department of Emergency Medicine, University of Florida College of Medicine, USA.
  • Hossain MS; Biomedical Research Foundation, Dhaka, Bangladesh.
  • Siddiqee MH; Biomedical Research Foundation, Dhaka, Bangladesh.
  • Islam MZ; Department of Community Medicine, National Institute of Preventive and Social Medicine, Mohakhali, Dhaka, Bangladesh.
  • Raheem E; Biomedical Research Foundation, Dhaka, Bangladesh.
  • Uddin MJ; Department of Statistics (Biostatistics and Epidemiology), Shahjalal University of Science & Technology, Sylhet, Bangladesh.
J Prev Med Hyg ; 62(2): E329-E371, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-1355287
ABSTRACT

OBJECTIVES:

We aimed to estimate the prevalence of reported symptoms and comorbidities, and investigate the factors associated with age of the SARS-CoV-2 infected patients.

METHODS:

We performed a systematic review with meta-analysis (PROSPERO registration CRD42020182677) where the databases (PubMed, SCOPUS, EMBASE, WHO, Semantic Scholar, and COVID-19 Primer) were searched for clinical studies published from January to April, 2020. Initially, the pooled prevalence of symptoms and comorbidity of COVID-19 patients were estimated using random effect model and the age -related factors were identified performing multivariate analysis [factor analysis].

RESULTS:

Twenty-nine articles with 4,884 COVID-19 patients were included in this study. Altogether, we found 33 symptoms and 44 comorbidities where the most frequent 19 symptoms and 11 comorbidities were included in the meta-analysis. The fever (84%), cough/dry cough (61%), and fatigue/weakness (42%) were found more prevalent while acute respiratory distress syndrome, hypertension and diabetes were the most prevalent comorbid condition. The factor analysis showed positive association between a cluster of symptoms and comorbidities with patients' age. The symptoms comprising fever, dyspnea/shortness of breath, nausea, vomiting, abdominal pain, dizziness, anorexia and pharyngalgia; and the comorbidities including diabetes, hypertension, coronary heart disease, COPD/lung disease and ARDS were the factors positively associated with COVID-19 patient's age.

CONCLUSION:

As an unique effort, this study found a group of symptoms (fever, dyspnea/shortness of breath, nausea, vomiting, abdominal pain, dizziness, anorexia and pharyngalgia) and comorbidities (diabetes, hypertension, coronary heart disease, COPD/lung disease and ARDS), associated with the age of COVID-19 infected patients.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pandemias / COVID-19 Tipo de estudo: Estudo de etiologia / Estudo de prevalência / Estudo prognóstico / Ensaios controlados aleatórios / Revisão / Fatores de risco / Revisão sistemática Limite: Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Prev Med Hyg Assunto da revista: Saúde Pública Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: 2421-4248

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pandemias / COVID-19 Tipo de estudo: Estudo de etiologia / Estudo de prevalência / Estudo prognóstico / Ensaios controlados aleatórios / Revisão / Fatores de risco / Revisão sistemática Limite: Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Prev Med Hyg Assunto da revista: Saúde Pública Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: 2421-4248