Vitamin D Status and Severe COVID-19 Disease Outcomes in Hospitalized Patients.
J Prim Care Community Health
; 12: 21501327211041206, 2021.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1376564
ABSTRACT
BACKGROUND:
Vitamin D deficiency may increase the risk of severe COVID-19 disease.OBJECTIVES:
To determine if 25-hydroxyvitamin D [25(OH)D] levels in patients hospitalized for COVID-19 were associated with the clinical outcomes of days on oxygen, duration of hospitalization, ICU admission, need for assisted ventilation, or mortality.METHODS:
We conducted a retrospective study of 92 patients admitted to the hospital with SARS-CoV-2 infection between April 16, 2020 and October 17, 2020. Multivariable regression was performed to assess the independent relationship of 25(OH)D values on outcomes, adjusting for significant covariates and the hospitalization day the level was tested.RESULTS:
About 15 patients (16.3%) had 25(OH)D levels <20 ng/mL. Only 1 patient (3.4%) who had documented vitamin D supplementation prior to admission had 25(OH)D <20 ng/mL. Serum 25(OH)D concentrations were not significantly associated with any of our primary outcomes of days on oxygen, duration of hospitalization, intensive care unit (ICU) admission, need for mechanical ventilation, or mortality in any of the adjusted multivariable models. Adjusting for the hospital day of 25(OH)D sampling did not alter the relationship of 25(OH)D with any outcomes.CONCLUSION:
Vitamin D status was not related to any of the primary outcomes reflecting severity of COVID-19 in hospitalized patients. However, our sample size may have lacked sufficient power to demonstrate a small effect of vitamin D status on these outcomes.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina D
/
COVID-19
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Tópicos:
Covid persistente
Limite:
Humanos
Idioma:
Inglês
Revista:
J Prim Care Community Health
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
21501327211041206
Similares
MEDLINE
...
LILACS
LIS