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Management of Patients With Glucocorticoid-Related Diseases and COVID-19.
Chifu, Irina; Detomas, Mario; Dischinger, Ulrich; Kimpel, Otilia; Megerle, Felix; Hahner, Stefanie; Fassnacht, Martin; Altieri, Barbara.
  • Chifu I; Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany.
  • Detomas M; Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany.
  • Dischinger U; Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany.
  • Kimpel O; Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany.
  • Megerle F; Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany.
  • Hahner S; Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany.
  • Fassnacht M; Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany.
  • Altieri B; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
Front Endocrinol (Lausanne) ; 12: 705214, 2021.
Artigo em Inglês | MEDLINE | ID: covidwho-1448725
ABSTRACT
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health crisis affecting millions of people worldwide. SARS-CoV-2 enters the host cells by binding to angiotensin-converting enzyme 2 (ACE2) after being cleaved by the transmembrane protease serine 2 (TMPRSS2). In addition to the lung, gastrointestinal tract and kidney, ACE2 is also extensively expressed in endocrine tissues, including the pituitary and adrenal glands. Although glucocorticoids could play a central role as immunosuppressants during the cytokine storm, they can have both stimulating and inhibitory effects on immune response, depending on the timing of their administration and their circulating levels. Patients with adrenal insufficiency (AI) or Cushing's syndrome (CS) are therefore vulnerable groups in relation to COVID-19. Additionally, patients with adrenocortical carcinoma (ACC) could also be more vulnerable to COVID-19 due to the immunosuppressive state caused by the cancer itself, by secreted glucocorticoids, and by anticancer treatments. This review comprehensively summarizes the current literature on susceptibility to and outcome of COVID-19 in AI, CS and ACC patients and emphasizes potential pathophysiological mechanisms of susceptibility to COVID-19 as well as the management of these patients in case of SARS-CoV-2. Finally, by performing an in silico analysis, we describe the mRNA expression of ACE2, TMPRSS2 and the genes encoding their co-receptors CTSB, CTSL and FURIN in normal adrenal and adrenocortical tumors (both adenomas and carcinomas).
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: COVID-19 / Glucocorticoides Tipo de estudo: Estudo experimental / Estudo prognóstico / Ensaios controlados aleatorizados Tópicos: Covid persistente Limite: Animais / Humanos Idioma: Inglês Revista: Front Endocrinol (Lausanne) Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Fendo.2021.705214

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: COVID-19 / Glucocorticoides Tipo de estudo: Estudo experimental / Estudo prognóstico / Ensaios controlados aleatorizados Tópicos: Covid persistente Limite: Animais / Humanos Idioma: Inglês Revista: Front Endocrinol (Lausanne) Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Fendo.2021.705214