Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.
PLoS One
; 16(10): e0258820, 2021.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1470667
ABSTRACT
BACKGROUND AND OBJECTIVE:
The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of vaccination are poorly understood. Our objective was to determine the risk factors for breakthrough SARS-CoV-2 infection among HCWs at a national healthcare system in Qatar.METHODS:
We identified all HCWs at Hamad Medical Corporation in Qatar between December 20, 2020 and May 18, 2021 with confirmed SARS-CoV-2 RT-PCR infection >14 days after the second vaccine dose. For each case thus identified, we identified one control with a negative test after December 20, 2020, matched on age, sex, nationality, job family and date of SARS-CoV-2 testing. We excluded those with a prior positive test and temporary workers. We used Cox regression analysis to determine factors associated with breakthrough infection.RESULTS:
Among 22,247 fully vaccinated HCW, we identified 164 HCW who had breakthrough infection and matched them to 164 controls to determine the factors associated with SARS-CoV-2 breakthrough infection. In the breakthrough infection group the nursing and midwifery job family constituted the largest group, spouse was identified as the most common positive contact followed by a patient. Exposure to a confirmed case, presence of symptoms and all other job families except Allied Health Professionals when compared with nursing and Midwifery staff independently predicted infection.CONCLUSION:
Presence of symptoms and contact with a confirmed case are major risk factors for breakthrough SARS-CoV-2 infection after vaccination, and these groups should be prioritized for screening even after full vaccination.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Vacinação
/
Pessoal de Saúde
/
Vacinas contra COVID-19
/
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
/
Ensaios controlados aleatorizados
Tópicos:
Vacinas
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
/
Meia-Idade
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
PLoS One
Assunto da revista:
Ciência
/
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Journal.pone.0258820
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