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Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters.
Kinoshita, Takaaki; Watanabe, Kenichi; Sakurai, Yasuteru; Nishi, Kodai; Yoshikawa, Rokusuke; Yasuda, Jiro.
  • Kinoshita T; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.
  • Watanabe K; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan.
  • Sakurai Y; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
  • Nishi K; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.
  • Yoshikawa R; National Research Center for the Control and Prevention of Infectious Diseases (CCPID), Nagasaki University, Nagasaki, Japan.
  • Yasuda J; Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Sci Rep ; 11(1): 21259, 2021 10 28.
Artigo em Inglês | MEDLINE | ID: covidwho-1493217
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a serious public health concern worldwide. Notably, co-infection with other pathogens may worsen the severity of COVID-19 symptoms and increase fatality. Here, we show that co-infection with influenza A virus (IAV) causes more severe body weight loss and more severe and prolonged pneumonia in SARS-CoV-2-infected hamsters. Each virus can efficiently spread in the lungs without interference by the other. However, in immunohistochemical analyses, SARS-CoV-2 and IAV were not detected at the same sites in the respiratory organs of co-infected hamsters, suggesting that either the two viruses may have different cell tropisms in vivo or each virus may inhibit the infection and/or growth of the other within a cell or adjacent areas in the organs. Furthermore, a significant increase in IL-6 was detected in the sera of hamsters co-infected with SARS-CoV-2 and IAV at 7 and 10 days post-infection, suggesting that IL-6 may be involved in the increased severity of pneumonia. Our results strongly suggest that IAV co-infection with SARS-CoV-2 can have serious health risks and increased caution should be applied in such cases.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Infecções por Orthomyxoviridae / SARS-CoV-2 / COVID-19 Tipo de estudo: Estudo prognóstico Tópicos: Covid persistente Limite: Animais / Feminino / Humanos Idioma: Inglês Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: S41598-021-00809-2

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Infecções por Orthomyxoviridae / SARS-CoV-2 / COVID-19 Tipo de estudo: Estudo prognóstico Tópicos: Covid persistente Limite: Animais / Feminino / Humanos Idioma: Inglês Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: S41598-021-00809-2