Your browser doesn't support javascript.
Molecular docking identification for the efficacy of natural limonoids against COVID-19 virus main protease
Journal of the Indian Chemical Society ; 98(10):6, 2021.
Artigo em Inglês | Web of Science | ID: covidwho-1510017
ABSTRACT
COVID-19 pandemic is the biggest public health problem of the century so far.The main protease (Mpro) is one of the main enzymes studied as a pharmacological target. In this context, the present work aimed to perform a virtual screening of possible inhibitors against the enzyme Mpro, having limonoids as the main object of research as supposed inhibitors. Molecular docking simulations indicated that limonoids have an affinity to complex with M-pro.However, Limonine and Nimoliciol showed nonspecific and low affinity interactions. In conclusion, Limonoids are substances of natural origin that can be used in the study of new pharmacological tools designed to combat and understand COVID-19.

Texto completo: Disponível Coleções: Bases de dados de organismos internacionais Base de dados: Web of Science Idioma: Inglês Revista: Journal of the Indian Chemical Society Ano de publicação: 2021 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponível Coleções: Bases de dados de organismos internacionais Base de dados: Web of Science Idioma: Inglês Revista: Journal of the Indian Chemical Society Ano de publicação: 2021 Tipo de documento: Artigo