Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy.
Nat Med
; 27(10): 1693-1695, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1526092
ABSTRACT
To evaluate the effectiveness of the BNT162b2 messenger RNA vaccine in pregnant women, we conducted an observational cohort study of pregnant women aged 16 years or older, with no history of SARS-CoV-2, who were vaccinated between 20 December 2020 and 3 June 2021. A total of 10,861 vaccinated pregnant women were matched to 10,861 unvaccinated pregnant controls using demographic and clinical characteristics. Study outcomes included documented infection with SARS-CoV-2, symptomatic COVID-19, COVID-19-related hospitalization, severe illness and death. Estimated vaccine effectiveness from 7 through to 56 d after the second dose was 96% (95% confidence interval 89-100%) for any documented infection, 97% (91-100%) for infections with documented symptoms and 89% (43-100%) for COVID-19-related hospitalization. Only one event of severe illness was observed in the unvaccinated group and no deaths were observed in either group. In summary, the BNT162b2 mRNA vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Vacinas contra COVID-19
/
COVID-19
Tipo de estudo:
Estudo de coorte
/
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Vacinas
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Gravidez
/
Jovem adulto
Idioma:
Inglês
Revista:
Nat Med
Assunto da revista:
Biologia Molecular
/
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
S41591-021-01490-8
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