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Benefits and adverse events of melatonin use in the elderly (Review).
Anghel, Lucreția; Baroiu, Liliana; Popazu, Corina Rișca; Patraș, Diana; Fotea, Silvia; Nechifor, Alexandru; Ciubara, Anamaria; Nechita, Luiza; Mușat, Carmina Liana; Stefanopol, Ioana Anca; Tatu, Alin Laurențiu; Ciubara, Alexandru Bogdan.
  • Anghel L; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Baroiu L; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Popazu CR; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Patraș D; Internal Medicine Department, St. Andrew The Apostle Clinical Emergency County Hospital, 800578 Galați, Romania.
  • Fotea S; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Nechifor A; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Ciubara A; Multidisciplinary Integrated Center of Dermatological Interface Research, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Nechita L; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Mușat CL; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Stefanopol IA; Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Tatu AL; Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
  • Ciubara AB; Clinical Medical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800008 Galați, Romania.
Exp Ther Med ; 23(3): 219, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: covidwho-1667404
ABSTRACT
Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal pathways of transmission to the pineal gland. A significant decrease in melatonin synthesis has been reported in various disorders and diseases, including cardiovascular diseases, metabolic disorders (particularly diabetes type 2), cancer and endocrine diseases. In addition to the fact, that melatonin is a sleep inducer, it also exerts cytoprotective properties as an antioxidant and free radical scavenger. The therapeutic role of melatonin has been demonstrated in sleep disorders, eye damage and cardiovascular disease. The association between melatonin and ß-blockers has had a positive impact on sleep disorders in clinical trials. Previous studies have reported the anti-inflammatory effect of melatonin by adjusting levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1ß and tumor necrosis factor-α. Melatonin treatment has been demonstrated to decrease IL-6 and IL-10 expression levels and efficiently attenuate T-cell proliferation. Currently, there is an inconsistency of scientific data regarding the lowest optimal dose and safety of melatonin for long-term use. The aim of the present review was to summarize the evidence on the role of melatonin in various clinical conditions and highlight the future research in this area.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Exp Ther Med Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Etm.2022.11142

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo prognóstico Idioma: Inglês Revista: Exp Ther Med Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Etm.2022.11142