Comparative evaluation of serum lipid levels in COVID-19 patients before and after therapy

ABSTRACT

Introduction: Aims of this study were to investigate the pathological alterations in LDL-cholesterol, HDLcholesterol, total cholesterol, and triglycerides in individuals with COVID-19 infection. Methods:Between February and April 2020, a total of 80 COVID-19 patients admitted to our hospital and 80 patient recovered from COVID-19 were evaluated for their LDL- and HDL-cholesterol levels. 80 age and sex matched individual were included in the study for comparision. Lipid level were compared among the COVID-19 patient, patient recovered from COVID-19 and healthy control. Results:Over eighty percent of the covid-19 patients had cholesterol levels that were much lower than the normal person. Only total cholesterol indicated significant differences between healthy controls and COVID-19. There was a considerable increase in the levels of HDL, LDL (bad), and triglyceride levels after recovery compared to the acute stage of sickness. Low density lipoprotein (LDL) cholesterol and total cholesterol had a negative relationship with C-reactive protein (CRP). It is possible that lipids such as cholesterol are important in viral multiplication, internalisation and immunological activation in COVID-19 infected individuals, according to our data. Conclusions: In addition, it is possible to use lipid abnormalities discovered during and after infection as a proxy for assessing the effectiveness of therapeutic treatment.