Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models.
J Med Virol
; 94(10): 4754-4761, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1894609
ABSTRACT
Polymerase chain reaction (PCR) and antigen tests have been used extensively for screening during the severe acute respiratory syndrome coronavirus 2 pandemics. However, the real-world sensitivity and specificity of the two testing procedures in the field have not yet been estimated without assuming that the PCR constitutes a gold standard test. We use latent class models to estimate the in situ performance of both tests using data from the Danish national registries. We find that the specificity of both tests is very high (>99.7%), while the sensitivities are 95.7% (95% confidence interval [CI] 92.8%-98.4%) and 53.8% (95% CI 49.8%-57.9%) for the PCR and antigen tests, respectively. These findings have implications for the use of confirmatory PCR tests following a positive antigen test result:
we estimate that serial testing is counterproductive at higher prevalence levels.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Estudo diagnóstico
/
Estudo experimental
/
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
J Med Virol
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Jmv.27943
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